Gene transcription acceleration: main cause of hepatitis B surface antigen production improvement by dimethyl sulfoxide in the culture of Chinese hamster ovary cells
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Summary
It could be deduced that the acceleration ofHBsAg gene transcription is the main cause of HBsAg production improvement, when supplemented with 1.5% dimethyl sulfoxide (DMSO) in the culture medium.
- Type
- article
- Published
- 2007-06-15
- Cited by
- 26
- References
- 26
- OpenAlex
- https://openalex.org/W17099910
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23205177
Keywords
Humanities, Geography, Philosophy
References
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- Analysis of gene expression in the rat hippocampus using real time PCR reveals high inter‐individual variation in mRNA expression levels
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- Genes modulated by histone acetylation as new effectors of butyrate activity
- Dimethyl sulfoxide restores contact inhibition-induced growth arrest and inhibits cell density-dependent apoptosis in hamster cells.
- Pentanoic acid, a novel protein synthesis stimulant for Chinese Hamster Ovary (CHO) cells.
- Construction of engineered CHO strains for high-level production of recombinant proteins
- Multidisciplinary utilization of dimethyl sulfoxide: pharmacological, cellular, and molecular aspects.
- The effect of DMSO on natural DNA conformation in enhancing transcription.
- Stimulation of transcription on chromatin by polar organic compounds.
- Reversible G1 arrest induced by dimethyl sulfoxide in human lymphoid cell lines: dimethyl sulfoxide inhibits IL-6-induced differentiation of SKW6-CL4 into IgM-secreting plasma cells.
- Analysis of human interleukin-5 gene transcription by a novel nuclear run on method based on the polymerase chain reaction.
- Real-time PCR in virology.
Cited by
- Tools for next-generation transcriptional control in Chinese hamster ovary cell factories
- Cell Line and Process Development for Improved Transient Production of a "Difficult-to-Express" Fusion Protein by CHO Cells
- Enhanced plasmid DNA utilization in transiently transfected CHO–DG44 cells in the presence of polar solvents
- Transcriptional and post‐transcriptional limitations of high‐yielding, PEI‐mediated transient transfection with CHO and HEK‐293E cells
- Advances in Cell Culture Process Development: Tools and Techniques for Improving Cell Line Development and Process Optimization
- Effect of Bcl-xL overexpression on erythropoietin production in recombinant Chinese hamster ovary cells treated with dimethyl sulfoxide
- Enhanced intracellular accumulation of recombinant HBsAg in CHO cells by dimethyl sulfoxide
- Effect of chemical chaperone addition on production and aggregation of recombinant flag‐tagged COMP‐angiopoietin 1 in chinese hamster ovary cells
- Limitations in the process of transcription and translation inhibit recombinant human chorionic gonadotropin expression in CHO cells.
- Process analysis of reduced specific productivity of TNFR-Fc in Chinese hamster ovary cells at high cell density
- Production and N-glycosylation of recombinant human cell adhesion molecule L1 from insect cells using the stable expression system. Effect of dimethyl sulfoxide.
- An Increased Intracellular Calcium Ion Concentration in Response to Dimethyl Sulfoxide Correlates with Enhanced Expression of Recombinant Human Cyclooxygenase 1 in Stably Transfected Drosophila melanogaster S2 Cells
- Detailed understanding of enhanced specific productivity in Chinese hamster ovary cells at low culture temperature.
- Production and characterization of active recombinant interleukin‐12/eGFP fusion protein in stably‐transfected DF1 chicken cells
- Approaches to optimizing animal cell culture process: substrate metabolism regulation and protein expression improvement.
- Establishing a high titer transient gene expression process in conditioned media for CHO-DG44 cells
- Enhanced expression of recombinant human cyclooxygenase 1 from stably-transfected Drosophila melanogaster S2 cells by dimethyl sulfoxide is mediated by up-regulation of nitric oxide synthase and transcription factor Kr-h1
- Enhanced production of recombinant proteins by a small molecule protein synthesis enhancer in combination with an antioxidant in recombinant Chinese hamster ovary cells
- Baicalein Reduces Oxidative Stress in CHO Cell Cultures and Improves Recombinant Antibody Productivity.
- Lipopolysaccharide Induces The Production Of Diagnostic Monoclonal Antibody By Hybridoma Cells Against Congenital Adrenal Hyperplasia
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