The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells.
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Summary
Data indicate that honokiol is a potent inducer of apoptosis in B-CLL cells and should be examined for further clinical application either as a single agent or in combination with other anticancer agents.
- Type
- article
- Published
- 2004-11-16
- Cited by
- 199
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W1972475208
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23813365
Keywords
Honokiol, Chronic lymphocytic leukemia, Cladribine, Fludarabine, Cancer research
References
- Antimicrobial activity of phenolic constituents of Magnolia grandiflora L.
- Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1.
- bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia.
- Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses.
- Two antiplatelet agents from Magnolia officinalis.
- The clinical significance of tumor necrosis factor-alpha plasma level in patients having chronic lymphocytic leukemia.
- Clinical relevance of intracellular vascular endothelial growth factor levels in B-cell chronic lymphocytic leukemia.
- Chinese and Related North American Herbs: Phytopharmacology and Therapeutic Values
- B-CLL cells are capable of synthesis and secretion of both pro- and anti-angiogenic molecules
- Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells.
- CDDO induces apoptosis via the intrinsic pathway in lymphoid cells
- VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia.
- Sustained complete remission of CLL associated with the use of a Chinese herbal extract: case report and mechanistic analysis.
- STAT1 mediates differentiation of chronic lymphocytic leukemia cells in response to Bryostatin 1.
- Protection from apoptotic cell death by interleukin-4 is increased in previously treated chronic lymphocytic leukemia patients.
- Mcl‐1 and Bcl‐2/Bax ratio are associated with treatment response but not with Rai stage in B‐cell chronic lymphocytic leukemia
- Identification and determination of honokiol and magnolol from Magnolia officinalis by high-performance liquid chromatography with phtodiode-array UV detection
- Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance.
- Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma.
- Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.
Cited by
- Honokiol inhibits LPS‐induced maturation and inflammatory response of human monocyte‐derived dendritic cells
- Characterization of metabolic profile of honokiol in rat feces using liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and (13)C stable isotope labeling.
- Effects of fennel, asafetida and ginseng ethanolic extracts on growth and proliferation of mouse breast cancer 4T1 cell lines
- A Novel Natural Product, KL-21, Inhibits Proliferation and Induces Apoptosis in Chronic Lymphocytic Leukemia Cells
- Natural products-based insecticidal agents 20. Design, synthesis and insecticidal activity of novel honokiol/magnolol azo derivatives
- Study on Cytotoxic Activity of Clerodendrum inerme and Caesalpinia crista by Brine Shrimp Lethality Bioassay
- Honokiol inhibits gastric tumourigenesis by activation of 15‐lipoxygenase‐1 and consequent inhibition of peroxisome proliferator‐activated receptor‐γ and COX‐2‐dependent signals
- Physiological and Pharmacological Regulation of the STAT3 Pathway in Cancer
- Deguelin inhibits expression of IκBα protein and induces apoptosis of B-CLL cells in vitro
- Honokiol Induces Cell Cycle Arrest and Apoptosis Via Inhibiting Class I Histone Deacetylases in Acute Myeloid Leukemia
- Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest.
- Different Redox States in Malignant and Nonmalignant Esophageal Epithelial Cells and Differential Cytotoxic Responses to Bile Acid and Honokiol
- Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia.
- Poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCL-PEG-PCL) nanoparticles for honokiol delivery in vitro.
- Therapeutic applications of compounds in the Magnolia family.
- Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells
- Honokiol Induces Calpain-Mediated Glucose-Regulated Protein-94 Cleavage and Apoptosis in Human Gastric Cancer Cells and Reduces Tumor Growth
- Honokiol Attenuates the Severity of Acute Pancreatitis and Associated Lung Injury via Acceleration of Acinar Cell Apoptosis
- Induction of apoptosis by obovatol as a novel therapeutic strategy for acute myeloid leukemia.
- Antineoplastic effects of Magnoliae officinalis in tumours other than hepatomas
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