bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia.
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Summary
Differences in the relative levels of Bcl-2 protein among cases of B-CLL appeared to be functionally significant, in that a preliminary analysis of 3 representative cases showed that CLL cells with higher levels of P26-Bcl- 2 protein survived longer in culture and were delayed in their onset of DNA degradation relative to CLL Cells with lower BCl-2protein levels.
- Type
- article
- Published
- 1993-09-15
- Cited by
- 421
- References
- 46
- Access
- Open access
- OpenAlex
- https://openalex.org/W122353466
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2554582
Keywords
Chronic lymphocytic leukemia, Chromosomal translocation, Biology, Gene, Molecular biology
References
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- Activation of the c-myc oncogene in a precursor-B-cell blast crisis of follicular lymphoma, presenting as composite lymphoma.
- Regulation of c-myc mRNA levels in normal human lymphocytes by modulators of cell proliferation.
- Cooperative interaction between c-myc and bcl-2 proto-oncogenes
- Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death.
- Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas
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- Inhibidors de cinases com a estratègia terapèutica en neoplàsies limfoides
- Chemokine Receptors and Stromal Cells in the Homing and Homeostasis of Chronic Lymphocytic Leukemia B Cells
- Targeting Bcl-2 in CLL: cui bono?
- A chemoprotective fish oil/pectin diet enhances apoptosis via Bcl-2 promoter methylation in rat azoxymethane-induced carcinomas
- The BCL-2 family: key mediators of the apoptotic response to targeted anti-cancer therapeutics
- The interplay between the expression and functions of Wnt13 isoforms during apoptosis in bovine aortic endothelial cells
- National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment.
- INVESTIGATING APOPTOSIS PATHWAY IN CHRONIC LYMPHOCYTIC LEUKEMIA: STROMAL INFLUENCE AND THERAPEUTIC ACTIVATION
- HIGH DOSE SIMVASTATIN AS A POTENTIAL ANTICANCER THERAPY IN LEUKEMIA PATIENTS
- Biology of Chronic Lymphocytic Leukemia in Different Microenvironments: Clinical and Therapeutic Implications
- Evaluation of LMP-420: A Novel, Nontoxic Drug with Anti-Inflammatory Properties and Therapeutic Potential for CLL
- Immunologie de la polypose nasosinusienne
- Epigenomics: genome-wide study of methylation phenomena.
- Targeting the anti-apoptotic Bcl-2 family members for the treatment of cancer.
- Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses.
- Genetic instability in human tumors.
- The effect of chronic preconception paternal alcohol intake on sperm methylation signatures and subsequent gene expression in mouse offspring
- Differential induction of apoptosis by fludarabine monophosphate in leukemic B and normal T cells in chronic lymphocytic leukemia.
- Enzyme-linked immunosorbent assay in screening of leukemia-associated nuclear proteins.
- Expression et fonctionnalité des Toll-Like récepteurs par les cellules de leucémie lymphoïde chronique B
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