Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.
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Summary
The purification of a cytosolic protein that induces cytochrome c release from mitochondria in response to caspase-8, the apical caspases activated by cell surface death receptors such as Fas and TNF is reported.
- Type
- article
- Published
- 1998-08-21
- Cited by
- 3,889
- References
- 73
- Access
- Open access
- OpenAlex
- https://openalex.org/W2012173926
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7970766
Keywords
Cytochrome c, Biology, Mitochondrion, Cell biology, Apoptosome
References
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- Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product (*)
- Two CD95 (APO‐1/Fas) signaling pathways
- Loss of Function of Cytochrome c in Jurkat Cells Undergoing Fas-mediated Apoptosis*
- Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria.
- Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
- Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
- Apoptosis in the pathogenesis and treatment of disease
- Bcl-xL forms an ion channel in synthetic lipid membranes
- Apoptosis by death factor.
- Bax directly induces release of cytochrome c from isolated mitochondria.
- Bcl-xL Acts Downstream of Caspase-8 Activation by the CD95 Death-inducing Signaling Complex*
- Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.
- The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis.
- Programmed cell death in animal development.
Cited by
- La protéine de stress Hsp27 / HspB1, une cible de choix en thérapie anti-cancéreuse
- Molecular interactions of Salmonella with the host epithelium in the presence of commensals
- Investigation of the ubiquitin-specific protease UBP41 and of the lysosomal cysteine proteases cathepsin-L and cathepsin-B as potential mediators of proapoptotic signalling
- Caspase-independent commitment phase to apoptosis in activated blood T lymphocytes: reversibility at low apoptotic insult.
- Characterization of a Small Molecule Smac Mimetic's Role in Inducing Apoptosis in Human Cancer Cells
- Hsp70: anti-apoptotic and tumorigenic protein.
- Cell-free apoptosis in Xenopus laevis egg extracts.
- The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.
- A Novel BH3-like Domain in BID Is Required for Intramolecular Interaction and Autoinhibition of Pro-apoptotic Activity*
- Mitochondria at the Crossroad of Apoptotic Cell Death
- The Molecular Mechanism of Programmed Cell Death in C. elegans
- Cleavage of Bax enhances its cell death function.
- MCL-1S, a Splicing Variant of the Antiapoptotic BCL-2 Family Member MCL-1, Encodes a Proapoptotic Protein Possessing Only the BH3 Domain*
- Mitochondria in the Programmed Death Phenomena; A Principle of Biology: “It Is Better to Die than to be Wrong”
- XIAP Regulates DNA Damage-induced Apoptosis Downstream of Caspase-9 Cleavage*
- Requirement for caspase activation in monocytic differentiation of myeloid leukemia cells
- 25-Hydroxycholesterol activates a cytochrome c release-mediated caspase cascade.
- The ‘harmless’ release of cytochrome c
- Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression
- Bid regulation of neuronal apoptosis.
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