Longikaurin E induces apoptosis of pancreatic cancer cells via modulation of the p38 and PI3K/AKT pathways by ROS
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Summary
It is suggested that Longikaurin E induced apoptosis of pancreatic cancer cells via ROS generation to modulate the p38 and PI3K/AKT pathways and could be a promising anti-pancreatic agent.
- Type
- article
- Published
- 2015-03-06
- Cited by
- 21
- References
- 60
- OpenAlex
- https://openalex.org/W1972319565
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16064160
Keywords
PI3K/AKT/mTOR pathway, Protein kinase B, Apoptosis, Pancreatic cancer, p38 mitogen-activated protein kinases
References
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Cited by
- Reactive Oxygen Species and Targeted Therapy for Pancreatic Cancer
- Cytotoxicity effect of graphene oxide on human MDA-MB-231 cells
- A phase I trial of mFOLFOX6 combined with the oral PI3K inhibitor BKM120 in patients with advanced refractory solid tumors
- Natural compounds for pediatric cancer treatment
- 5-Hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone, a polymethoxyflavone, exerts antitumor effect on PI3K/Akt signaling pathway in human gastric cancer cell BGC-7901
- Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathway
- α-Mangostin, a Natural Agent, Enhances the Response of NRAS Mutant Melanoma to Retinoic Acid
- Dihydroartemisinin induces apoptosis in human gastric cancer cell line BGC-823 through activation of JNK1/2 and p38 MAPK signaling pathways
- Easy-to-use strategy for reference gene selection in quantitative real-time PCR experiments
- Desumoylating Isopeptidase 2 (DESI2) Inhibits Proliferation and Promotes Apoptosis of Pancreatic Cancer Cells through Regulating PI3K/AKT/mTOR Signaling Pathway
- Two novel 1,4-naphthoquinone derivatives induce human gastric cancer cell apoptosis and cell cycle arrest by regulating reactive oxygen species-mediated MAPK/Akt/STAT3 signaling pathways
- Tephrosin induces apoptosis of human pancreatic cancer cells through the generation of reactive oxygen species
- Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway
- Development of Graphene Oxide Nanosheets as Potential Biomaterials in Cancer Therapeutics: An In-Vitro Study Against Breast Cancer Cell Line
- Novel therapeutic strategies and perspectives for pancreatic cancer: Autophagy and apoptosis are key mechanisms to fight pancreatic cancer
- Apoptosis Triggering, an Important Way for Natural Products From Herbal Medicines to Treat Pancreatic Cancers
- Laminarin Attenuates ROS-Mediated Cell Migration and Invasiveness through Mitochondrial Dysfunction in Pancreatic Cancer Cells
- Targeting mitochondrial dysfunctions in pancreatic cancer evokes new therapeutic opportunities.
- Comparison of Tumour-Specific Phenotypes in Human Primary and Expandable Pancreatic Cancer Cell Lines
- Evodiamine inhibits proliferation of human papillary thyroid cancer cell line K 1 by regulating of PI 3 K / Akt signaling pathway
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