Respiratory Syncytial Virus Fusion Protein Promotes TLR-4–Dependent Neutrophil Extracellular Trap Formation by Human Neutrophils
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Summary
It is proposed that targeting the binding of TLR-4 by F protein could potentially lead to novel therapeutic approaches to help control RSV-induced inflammatory consequences and pathology of viral bronchiolitis.
- Type
- article
- Published
- 2015-04-09
- Cited by
- 176
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W1971749790
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2812475
Keywords
Neutrophil extracellular traps, Neutrophil elastase, Extracellular, Myeloperoxidase, Fusion protein
References
- Structural characterization of the human respiratory syncytial virus fusion protein core.
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- Neutrophil extracellular traps (NETs): Double-edged swords of innate immunity
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- The Respiratory Syncytial Virus Fusion Protein and Neutrophils Mediate the Airway Mucin Response to Pathogenic Respiratory Syncytial Virus Infection
- Local IL-17A Potentiates Early Neutrophil Recruitment to the Respiratory Tract during Severe RSV Infection
- Role of nasal interleukin-8 in neutrophil recruitment and activation in children with virus-induced asthma.
- Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
- Respiratory syncytial virus affects pulmonary function in BALB/c mice.
- Release of neutrophil elastase and its role in tissue injury in acute inflammation: effect of the elastase inhibitor, FR134043.
- Reactive oxygen species‐induced activation of ERK and p38 MAPK mediates PMA‐induced NETs release from human neutrophils
- The interaction of neutrophils with respiratory epithelial cells in viral infection
- Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.
- CXCR2 mediates NADPH oxidase–independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation
- Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation.
- Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps.
- Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms
Cited by
- Update on the spider and the fly: An extended commentary on “Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-Oxidase activation”
- LAIR-1 limits neutrophil extracellular trap formation in viral bronchiolitis.
- Neutrophil extracellular traps cause airway obstruction during respiratory syncytial virus disease
- Neutrophils in respiratory syncytial virus infection: A target for asthma prevention
- Human Respiratory Syncytial Virus: Role of Innate Immunity in Clearance and Disease Progression
- Open Peer Review
- Neutrophil Extracellular Traps in Respiratory Disease: guided anti-microbial traps or toxic webs?
- Transforming Growth Factor-β-Activated Kinase 1 Is Required for Human FcγRIIIb-Induced Neutrophil Extracellular Trap Formation
- Neutrophil Extracellular Traps in Pulmonary Diseases: Too Much of a Good Thing?
- Neutrophil Extracellular Traps Go Viral
- NETosis in Cancer – Platelet–Neutrophil Crosstalk Promotes Tumor-Associated Pathology
- Neutrophil extracellular traps in health and disease.
- Novel insights in the pathogenesis of infectious laryngotracheitis and bronchitis viruses in chickens
- Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment
- Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection
- Respiratory syncytial virus infection: an innate perspective
- Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants
- Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview
- Enhancing the neutrophil-mediated anti-cancer response after oncolytic measles virus therapy in B cell malignancy: dissecting out the mechanism
- Modulation of the host immune response by respiratory syncytial virus proteins
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