Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Explore this paper's citation graph
Summary
It is proposed that platelet TLR4 is a threshold switch for this new bacterial trapping mechanism in severe sepsis, where NETs have the greatest capacity for bacterial trapping.
- Type
- article
- Published
- 2007-04-01
- Cited by
- 2,331
- References
- 39
- OpenAlex
- https://openalex.org/W1986282241
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22372863
Keywords
Neutrophil extracellular traps, TLR4, Platelet, Sepsis, Extracellular
References
- Platelet‐induced neutrophil activation: platelet‐expressed fibrinogen induces the oxidative burst in neutrophils by an interaction with CD11C/CD18
- Differential leukocyte recruitment from whole blood via endothelial adhesion molecules under shear conditions.
- Functional α4-integrin: A newly identified pathway of neutrophil recruitment in critically ill septic patients
- Coagulation system and platelets are fully activated in uncomplicated sepsis
- Platelet Recruitment in the Murine Hepatic Microvasculature During Experimental Sepsis: Role of Neutrophils
- The role of selectins and integrins in adenovirus vector‐induced neutrophil recruitment to the liver
- Review: Role of Blood Platelets in Infection and Inflammation
- Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin.
- Bacterial clearance in the intact and regenerating liver.
- Rules of recruitment for Th1 and Th2 lymphocytes in inflamed liver: a role for alpha-4 integrin and vascular adhesion protein-1.
- A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature.
- Neutrophils mediate pulmonary vasomotor dysfunction in endotoxin-induced acute lung injury.
- Endotoxin, septic shock and acute lung injury: Neutrophils, macrophages and inflammatory mediators
- An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps.
- Platelets express functional Toll-like receptor-4.
- Platelet function in sepsis
- Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo.
- Hematologic disorders in critically ill patients.
- Molecular control of neutrophil apoptosis
- Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor
Cited by
- Coagulation and inflammation
- Tsetse Salivary Gland Proteins 1 and 2 Are High Affinity Nucleic Acid Binding Proteins with Residual Nuclease Activity
- Neutrophils, IL-1β, and gout: is there a link?
- NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury
- The NET, the trap and the pathogen: neutrophil extracellular traps in cutaneous immunity
- Paradoxical Roles of the Neutrophil in Sepsis: Protective and Deleterious
- Platelets and coagulation in infection
- Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria.
- The posttraumatic activation of CD4+ T regulatory cells is modulated by TNFR2- and TLR4-dependent pathways, but not by IL-10.
- The Platelet Response to Tissue Injury
- Untangling “NETosis” from NETs
- Serum and Serum Albumin Inhibit in vitro Formation of Neutrophil Extracellular Traps (NETs)
- Sepsis and Pediatric Acute Respiratory Distress Syndrome
- A Narrative Review: The Role of NETs in Acute Respiratory Distress Syndrome/Acute Lung Injury
- Regulation of hepatic inflammation and thrombosis during Salmonella infections
- Effect of Toll-like Receptor agonists on platelet activation in Acute Coronary Syndromes
- Rôle fonctionnel du Toll-Like Receptor 4 exprimé par les plaquettes sanguines en tant que cellules inflammatoires de l'immunité
- Mechanism of Ascorbate Protection Against Sepsis-Induced Capillary Blood Flow Impairment
- Characterization of the acute phase response in critically ill children
- The distribution and pro-inflammatory impact of titanium debris accumulation in the peri-implant environment
Related papers
- A novel rapid Neutrophil Extracellular Trap (NET) release mechanism without neutrophil death
- Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis
- A High-throughput Assay to Assess and Quantify Neutrophil Extracellular Trap Formation
- Evaluation of Circulating Markers of Neutrophil Extracellular Trap (NET) Formation as Risk Factors for Diabetic Retinopathy in a Case-Control Association Study
- Quantification of Neutrophil Extracellular Trap (NET)Formation in Healthy Subjects
- A High-throughput Assay to Assess and Quantify Neutrophil Extracellular Trap Formation.
- Progress in the study of neutrophil extracellular trap and related diseases
- Role for platelet toll-like receptor 4 (TLR4) in the formation of Neutrophil Extracellular Traps (NETs) in sepsis (44.22)
- Platelet activation and neutrophil extracellular trap (NET) formation in immune thrombocytopenia: is there an association?
- Novel mechanisms of thrombo-inflammation during infection: spotlight on neutrophil extracellular trap-mediated platelet activation.