Sphingosine 1-phosphate as a therapeutic agent
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Summary
Radiation-induced oocyte loss in adult female mice, the event that drives premature ovarian failure and infertility in female cancer patients, was completely prevented by in vivotherapy with S1P, the ligand for five G protein-coupled receptors.
- Type
- review
- Published
- 2002-09-01
- Cited by
- 127
- References
- 81
- OpenAlex
- https://openalex.org/W2005071794
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26935773
Keywords
Sphingosine-1-phosphate, Sphingosine, Phosphate, Pharmacology, Medicine
References
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- Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells.
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- Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy
- Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1).
- Liposomal N,N,N-trimethylsphingosine (TMS) as an inhibitor of B16 melanoma cell growth and metastasis with reduced toxicity and enhanced drug efficacy compared to free TMS: cell membrane signaling as a target in cancer therapy III.
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- Ras and Rho GTPases: a family reunion.
- Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway.
- 1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase.
- Involvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation
- Sphingolipid metabolism and cell growth regulation
- Stimulation of sphingosine-1-phosphate formation by the P2Y(2) receptor in HL-60 cells: Ca(2+) requirement and implication in receptor-mediated Ca(2+) mobilization, but not MAP kinase activation.
- Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide
- Sphingosine 1-Phosphate Inhibits Activation of Caspases that Cleave Poly(ADP-ribose) Polymerase and Lamins during Fas- and Ceramide-mediated Apoptosis in Jurkat T Lymphocytes*
- Divergence in Signal Transduction Pathways of Platelet-derived Growth Factor (PDGF) and Epidermal Growth Factor (EGF) Receptors
- Bimodal Regulation of Ceramidase by Interleukin-1β
Cited by
- Sphingolipid analysis by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).
- Therapeutic potential of targeting SK1 in human cancers.
- Method development for the analysis of bioactive lipids by liquid chromatography tandem mass spectrometry (LC-MS-MS)
- Lipid generation and signaling in ovarian cancer.
- Sphingosine 1-phosphate enhances excitability of sensory neurons through sphingosine 1-phosphate receptors 1 and/or 3
- Safety and risk assessment of ceramide 3 in cosmetic products.
- Studies of cell migration and programmed cell death: characterization and analysis of scattershot, a mutation disrupting germ cell migration and programmed cell death in Drosophila melanogaster
- Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation.
- Lysophospholipide induzieren Calcium- und pH-Änderungen in muriner Mikroglia
- Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development.
- Sphingosine-1-phosphate suppresses cyclophosphamide induced follicle apoptosis in human fetal ovarian xenografts in nude mice.
- Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease.
- Regulation of Autophagy and Its Associated Cell Death by “Sphingolipid Rheostat”
- Involvement of Smad Signaling in Sphingosine 1-Phosphate-mediated Biological Responses of Keratinocytes*
- Transcriptional Regulation of the Human Neutral Ceramidase Gene
- Dose-Dependent Effect of Sphingosine-1-Phosphate in Mouse Oocyte Maturation Medium on Subsequent Embryo Development
- Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action
- Sphingomyelin in the suppression of colon tumors: prevention versus intervention.
- Slow-freezing versus vitrification for human ovarian tissue cryopreservation
- Deactivation of Sphingosine Kinase 1 by Protein Phosphatase 2A*
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