Selenium in the redox regulation of the Nrf2 and the Wnt pathway.
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Summary
Not only healthy cells but also malignant ones benefit from intact Keap1/Nrf2 signaling, making a dysregulated hydroperoxide signaling a plausible explanation for the increased cancer risk in selenium deficiency.
- Type
- article
- Published
- 2013-01-01
- Cited by
- 55
- References
- 96
- OpenAlex
- https://openalex.org/W19851831
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6354184
Keywords
Selenocysteine, Wnt signaling pathway, KEAP1, Cell biology, Chemistry
References
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- You Wnt some, you lose some: oncogenes in the Wnt signaling pathway.
Cited by
- Supplementation with Brazil nuts and green tea extract regulates targeted biomarkers related to colorectal cancer risk in humans
- Gestational Form of Supplemental Selenium (Se) Affects Steroidogenic Gene Expression in the Newborn Calf Testis
- Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage.
- Changes in Caco-2 cells transcriptome profiles upon exposure to gold nanoparticles.
- Crosstalk between Nrf2 and Notch signaling
- Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway.
- Cyto-genotoxicity assessment of potential radioprotector, 3,3'-diselenodipropionic acid (DSePA) in Chinese Hamster Ovary (CHO) cells and human peripheral blood lymphocytes.
- Selenium-enriched polysaccharides from Pyracantha fortuneana (Se-PFPs) inhibit the growth and invasive potential of ovarian cancer cells through inhibiting β-catenin signaling
- Interplay between cytosolic disulfide reductase systems and the Nrf2/Keap1 pathway
- Selenium and redox signaling.
- Individual effects of different selenocompounds on the hepatic proteome and energy metabolism of mice.
- The effects of fenvalerate on hepatic and cerebral xenobiotic metabolizing enzymes in selenium and/or iodine deficient rats
- Redox Control of Skeletal Muscle Regeneration
- Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells
- Low-Dose Dose–Response for In Vitro Nrf2-ARE Activation in Human HepG2 Cells
- Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line.
- Various Mechanisms Involve the Nuclear Factor (Erythroid-Derived 2)-Like (NRF2) to Achieve Cytoprotection in Long-Term Cisplatin-Treated Urothelial Carcinoma Cell Lines
- Molecular characterization and metal induced gene expression of the novel glutathione peroxidase 7 from the chordate invertebrate Ciona robusta.
- Biomedical effects of selenium in a human organism
- Protective effect of low molecular-weight seleno-aminopolysaccharides against H2O2-induecd oxidative stress in intestinal epithelial cells.
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