Elf5 conditional knockout mice reveal its role as a master regulator in mammary alveolar development: failure of Stat5 activation and functional differentiation in the absence of Elf5.
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Summary
A model for Elf5-mediated alveolar development is proposed, in which Elf5 regulates the expression of key mediators of the PrlR/Jak2/Stat5 signaling pathway.
- Type
- article
- Published
- 2009-05-15
- Cited by
- 148
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W1967061237
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20982435
Keywords
STAT5, Conditional gene knockout, Biology, Internal medicine, Endocrinology
References
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- The ETS-domain transcription factor family
- A family of cytokine-inducible inhibitors of signalling
- Claudin 7 expression and localization in the normal murine mammary gland and murine mammary tumors
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- Socs2 and elf5 mediate prolactin-induced mammary gland development.
- SOCS-1, -2, -3: selective targets and functions downstream of the prolactin receptor.
- Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation
- IKKα Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development
- Elf5 is an epithelium‐specific, fibroblast growth factor–sensitive transcription factor in the embryonic lung
- Lactation defect in mice lacking the helix–loop–helix inhibitor Id2
- Ets transcription factors and human disease.
- Information networks in the mammary gland
- Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2.
- Multiple chromosomal mechanisms generate an EWS/FLI1 or an EWS/ERG fusion gene in Ewing tumors.
- Mammary epithelial cells are not able to undergo pregnancy-dependent differentiation in the absence of the helix-loop-helix inhibitor Id2.
- The Ets transcription factor Elf5 specifies mammary alveolar cell fate.
- Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism
Cited by
- Epigenetic Modifications Unlock the Milk Protein Gene Loci during Mouse Mammary Gland Development and Differentiation
- Effect of the normal mammary differentiation regulator ELF5 upon clinical outcomes of triple negative breast cancers patients
- Heterogeneity and Plasticity of Breast Cancer Stem Cells.
- Stromal Modulation of Radiation Carcinogenesis in Breast Cancer
- Investigating the role of the imprinted Grb10 gene in the regulation of maternal nutrient transfer.
- Proteomic Analysis of Mammary Epithelial Cell Development
- Role of the WNT-regulated transcription cofactor LBH in normal and neoplastic mammary stem cell control
- Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC
- Etude des cellules souches et progénitrices mammaires et de leur contribution à la tumorigenèse : rôle des facteurs de transcription Myc et p53
- Investigating the role of Integrin Linked Kinase in mammary epithelial cell differentiation
- Functional analysis of the KDM5B demethylase : in vitro and in vivo studies
- Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool
- Role of C/EBPβ in two luminal progenitor populations in the mouse mammary gland
- A Flt3 and Ras-dependent Pathway Primes B Cell Development by Inducing A State of IL7-responsiveness
- Hormone-Sensing Mammary Epithelial Progenitors: Emerging Identity and Hormonal Regulation
- Endocrine hormones and local signals during the development of the mouse mammary gland
- Lineage Specific Methylation of the Elf5 Promoter in Mammary Epithelial Cells
- Genome-wide search identifies Ccnd2 as a direct transcriptional target of Elf5 in mouse mammary gland
- From milk to malignancy: the role of mammary stem cells in development, pregnancy and breast cancer
- ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation
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