Bilirubin is an antioxidant of possible physiological importance.
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Summary
The data support the idea of a "beneficial" role for bilirubin as a physiological, chain-breaking antioxidant.
- Type
- article
- Published
- 1987-02-27
- Cited by
- 3,560
- References
- 28
- OpenAlex
- https://openalex.org/W1966582616
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27721110
Keywords
Antioxidant, Bilirubin, Chemistry, Liposome, Lipid peroxidation
References
- Prooxidant states and tumor promotion.
- Taurine: biological update.
- The ready isomerization of bilirubin IX- in aqueous solution.
- Will antioxidant nutrients slow aging processes?
- Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system.
- Oxidation of lipids. VIII. Synergistic inhibition of oxidation of phosphatidylcholine liposome in aqueous dispersion by vitamin E and vitamin C.
- Fluidity, permeability and antioxidant behaviour of model membranes incorporated with α-tocopherol and vitamin E acetate
- Autoxidation of biological molecules. 1. Antioxidant activity of vitamin E and related chain-breaking phenolic antioxidants in vitro
- Lipid composition and permeability of liposomes.
- Oxidation of Lipids. I. Quantitative Determination of the Oxidation of Methyl Linoleate and Methyl Linolenate
- Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes?
- Formation of alpha-tocopherol complexes with fatty acids. A hypothetical mechanism of stabilization of biomembranes by vitamin E.
- beta-Carotene: an unusual type of lipid antioxidant.
- The biology of oxygen radicals.
- CHEMICAL REACTIVITY OF THE NUCLEIC ACID BASES. I. ANTIOXIDATIVE ABILITY OF THE NUCLEIC ACIDS AND THEIR RELATED SUBSTANCES ON THE OXIDATION OF UNSATURATED FATTY ACIDS.
- Oxygen-derived free radicals in postischemic tissue injury.
- Über eine biologische Bedeutung der Gallenfarbstoffe. Bilirubin und Biliverdin als Antioxydantien für das Vitamin A und die essentiellen Fettsäuren
- 'Like a shrivelled blood orange'--bilirubin, jaundice, and phototherapy.
- Autoxidation of polyunsaturated lipids. Factors controlling the stereochemistry of product hydroperoxides
- Phototherapy for neonatal jaundice. Configurational isomers of bilirubin
Cited by
- Unraveling the Role of Hemeoxygenase-1/Carbon Monoxide in Pulmonary and Cardiovascular Diseases.
- Endogenous DNA damage as related to cancer and aging.
- Evaluation of the possible antioxidative role of bilirubin protecting from free radical related illnesses in neonates.
- Recovery from focal brain ischemia induced by extradural compression in diabetic and non-diabetic rats
- Retinopathy of prematurity and bilirubinno clinical evidence for a beneficial role of bilirubin as a physiological anti-oxidant
- Biological Antioxidant Defenses
- Modulation of cellular antioxidant defense activities by sodium arsenite in human fibroblasts
- Gene regulation of HBP 23 by metalloporphyrins and protoporphyrin IX in liver and hepatocyte cultures.
- Attenuation by glutathione of hsp72 gene expression induced by cadmium in cisplatin-resistant human ovarian cancer cells.
- Determinants of atherosclerosis susceptibility in the C3H and C57BL/6 mouse model: evidence for involvement of endothelial cells but not blood cells or cholesterol metabolism.
- Role of heme oxygenase-1 in hypoxia-reoxygenation: requirement of substrate heme to promote cardioprotection.
- Regulation of IL-1beta -induced GM-CSF production in human airway smooth muscle cells by carbon monoxide.
- Tissue-dependent induction of heme oxygenase-1 and metallothionein-1/2 by methyl methanesulfonate.
- The story so far: Molecular regulation of the heme oxygenase-1 gene in renal injury.
- Expression of heme oxygenase-1 is repressed by interferon-gamma and induced by hypoxia in human retinal pigment epithelial cells.
- Heme oxygenase-1 inhibition of MAP kinases, calcineurin/NFAT signaling, and hypertrophy in cardiac myocytes.
- A link between hyperbilirubinemia, oxidative stress and injury to neocortical synaptosomes.
- Effect of Targeted Deletion of the Heme Oxygenase-2 Gene on Hemoglobin Toxicity in the Striatum
- New signaling routes for an old drug: lipoxin A4 might mediate heme oxygenase-1 induction by aspirin. Focus on "Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells".
- L-methionine reduces oxidant stress in endothelial cells: Role of heme oxygenase-1, ferritin, and nitric oxide
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