Determinants of atherosclerosis susceptibility in the C3H and C57BL/6 mouse model: evidence for involvement of endothelial cells but not blood cells or cholesterol metabolism.
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Summary
Endothelial cells isolated from the aorta of B6 mice exhibited a dramatic induction of monocyte chemotactic protein-1, macrophage colony-stimulating factor, vascular cell adhesion molecule-2, and heme oxygenase-1 in response to minimally modified LDL, whereas endothelial cells from C3H mice showed little or no induction.
- Type
- article
- Published
- 2000-05-26
- Cited by
- 153
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W10827138
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2896003
Keywords
White matter, Cardiology, Atrophy, Medicine, Internal medicine
References
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- Low Density Lipoprotein Oxidation and Its Pathobiological Significance*
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- Carbon monoxide -- a "new" gaseous modulator of gene expression.
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- Influence of phthalates on glucose homeostasis and atherosclerosis in hyperlipidemic mice
- Association of a Vcam1 mutation with atherosclerosis susceptibility in diet-induced models of atherosclerosis.
- Glucose Regulates Interleukin-8 Production in Aortic Endothelial Cells through Activation of the p38 Mitogen-activated Protein Kinase Pathway in Diabetes*
- Circulating adhesion molecules in apoE-deficient mouse strains with different atherosclerosis susceptibility.
- Genetic Susceptibility of the Arterial Wall Is an Important Determinant of Atherosclerosis in C57BL/6 and FVB/N Mouse Strains
- Long-term exposure to oxidized low-density lipoprotein enhances tumor necrosis factor-alpha-stimulated endothelial adhesiveness of monocytes by activating superoxide generation and redox-sensitive pathways.
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- Oxidized lipids: The two faces of vascular inflammation
- Targeted Disruption of Endothelial Cell-selective Adhesion Molecule Inhibits Angiogenic Processes in Vitro and in Vivo*
- Innate immunity meets arteriogenesis: the versatility of toll-like receptors.
- Genetic factors in cardiovascular disease. 10 questions.
- Sex as a profound modifier of atherosclerotic lesion development in apolipoprotein E-deficient mice with different genetic backgrounds.
- Differential response of vascular smooth muscle cells to oxidized LDL in mouse strains with different atherosclerosis susceptibility.
- Molecular biology of atherosclerosis.
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