A bHLH interaction code controls bipotential differentiation and self-renewal in the Drosophila gut
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Summary
It is found that homodimers of Daughterless, homolog of mammalian E proteins, maintain self-renewal of intestinal stem cells (ISCs), antagonising the Enteroendocrine fate promoted by heterodimers of Da and Scute (Sc, homolog of ASCL).
- Type
- preprint
- Published
- 2019-06-27
- Cited by
- 1
- References
- 115
- Access
- Open access
- OpenAlex
- https://openalex.org/W2954190859
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:198266783
Keywords
Cell biology, Transcription factor, Biology, Stem cell, Cellular differentiation
References
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- Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut.
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- Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging
- Relationships between extramacrochaetae and Notch signalling in Drosophila wing development.
- Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages
- Niche Appropriation by Drosophila Intestinal Stem Cell Tumors
- Notch signalling and the initiation of neural development in the Drosophila eye.
- The HLH protein Extramacrochaetae is required for R7 cell and cone cell fates in the Drosophila eye
- Embryonic expression and function of the Drosophila helix-loop-helix gene, extramacrochaetae.
- Lineage selection and plasticity in the intestinal crypt
- On the existence of maximum likelihood estimates in logistic regression models
- Transcriptional control of stem cell maintenance in the Drosophila intestine
- i-cisTarget 2015 update: generalized cis-regulatory enrichment analysis in human, mouse and fly
Cited by
- Surprising features of nuclear receptor interaction networks revealed by live-cell single-molecule imaging
- Surprising features of nuclear receptor interaction networks revealed by live-cell single-molecule imaging
- Surprising Features of Nuclear Receptor Interaction Networks Revealed by Live Cell Single Molecule Imaging
- Synthetic multistability in mammalian cells
- Surprising Features of Nuclear Receptor Interaction Networks Revealed by Live Cell Single Molecule Imaging
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