Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells

Keywords

FOXP3, Cell biology, Transforming growth factor beta, CD28, Cytokine

References

• Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7Massimo Claudio Fantini, Christoph Becker, Giovanni Monteleone — 2004
• CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2Xuguang Tai, Michelle L. Cowan, Lionel Feigenbaum — 2005
• CD28 co-stimulation regulates the effect of transforming growth factor-beta1 on the proliferation of naïve CD4+ T cells.James L. Sung, Jack T. Lin, James D. Gorham — 2003
• Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory diseaseMarcia M. Shull, Ilona Ormsby, Ann B. Kier — 1992
• A function for interleukin 2 in Foxp3-expressing regulatory T cellsJason D. Fontenot, Jeffrey P. Rasmussen, Marc A. Gavin — 2005
• TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cellsJulien C. Marie, John J. Letterio, Marc A. Gavin — 2005
• Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3WanJun Chen, Wenwen Jin, Neil J. Hardegen — 2003
• Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsEstelle Bettelli, Yijun Carrier, Wenda Gao — 2006
• Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor FunctionAngela M. Thornton, Erin Donovan, Ciriaco A. Piccirillo — 2004
• Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.Shimon Sakaguchi — 2004
• Homeostatic maintenance of natural Foxp3 + CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralizationRuka Setoguchi, Shohei Hori, Takeshi Takahashi — 2005
• Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal periodAllison L. Bayer, Aixin Yu, Dennis O. Adeegbe — 2005

Cited by

• CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-β–dependent mannerStuart R. Cohn — 2008
• Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA MethylationMichael Federico Sciacca — 2009
• Simvastatin induces Foxp3+ T regulatory cells by modulation of transforming growth factor‐β signal transductionTim Hellmann — 2010
• Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes.V. M. Potapov, V. M. DEM'YANOVICH, V. Khlebnikov — 2012
• Role of the PD-1 Pathway in the Immune ResponseLeonardo V. Riella, Alison M. Paterson, Arlene H. Sharpe — 2012
• Metabolism of TH17 Cells: New Insights and Therapeutic Opportunities泰朗 野村 — 2016
• Regulation of Immunopathology in Mycobacterium tuberculosis infectionHillarie Plessner Windish — 2008
• CD28 costimulation in T cells : requirements, outcomes and regulationZoe Briggs — 2014
• Neutralization of IL-4 and IFN-γ Facilitates inducing TGF-β-induced CD4+Foxp3+ Regulatory CellsXiaojuan Tao, Jilin Ma, Yonghua Zhang — 2008
• A physiological role for inducible FOXP3(+) Treg cells. Lessons from women with reproductive failure.Lourdes Arruvito, Ana I. Sotelo, A. Billordo — 2010
• Influence des lymphocytes T CD4+ CD25+ régulateurs sur la dynamique de formation de la synapse immunologique entre un lymphocyte T CD4+ effecteur et une cellule présentatrice d'antigèneMichaël Esquerré — 2007
• Dendritic Cells are Both Targets and Initiators of Peripheral Immune Tolerance to SelfAdam M. Farkas — 2013
• Biological functions of regulatory T cells.Ethan M. Shevach — 2011
• Thymic and peripheral differentiation of regulatory T cells.Hyang-Mi Lee, Jhoanne L. Bautista, Chyi‐Song Hsieh — 2011
• The role of IL-2Rbeta-dependent signaling and CD103 in regulatory T cells for mucosal toleranceXiaomei Yuan — 2014
• The characterisation of human regulatory T cell subsets in ageing and atopyN. Booth — 2010
• System-wide approaches to uncover Th2 cell lineage commitmentTapio Lönnberg — 2012
• In vitro generation of human FOXP3+ regulatory T cellsGhusoon Abdulhameed Ebrahim Salman Abdulrasool — 2014
• Influencia de la catepsina L en la población de células T regulatorias CD4+: rol del estromaGabriela Camicia — 2011
• A CB2-Selective Cannabinoid Suppresses T-cell Activities and Increases Tregs and IL-10Rebecca Hartzell Robinson, Joseph J. Meissler, Xiaoxuan Fan — 2015

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