The role of miR-146a in dorsal root ganglia neurons of experimental diabetic peripheral neuropathy

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Summary

In vitro, blockage of miR-146a in DRG neurons abolished the effect of sildenafil on DRG neuron protection and downregulation of IRAK1 and TRAF6 proteins under hyperglycemia, providing the first evidence showing that miR-146a plays an important role in mediating DRG neuron apoptosis under hyperglycemic conditions.

Type
article
Published
2013-12-06
Cited by
84
References
42
Access
Open access

Keywords

Dorsal root ganglion, Downregulation and upregulation, Peripheral neuropathy, Medicine, Sensory neuron

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