The role of miR-146a in dorsal root ganglia neurons of experimental diabetic peripheral neuropathy
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Summary
In vitro, blockage of miR-146a in DRG neurons abolished the effect of sildenafil on DRG neuron protection and downregulation of IRAK1 and TRAF6 proteins under hyperglycemia, providing the first evidence showing that miR-146a plays an important role in mediating DRG neuron apoptosis under hyperglycemic conditions.
- Type
- article
- Published
- 2013-12-06
- Cited by
- 84
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W1964069071
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24897523
Keywords
Dorsal root ganglion, Downregulation and upregulation, Peripheral neuropathy, Medicine, Sensory neuron
References
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- Mechanistic Role of MicroRNA-146a in Endotoxin-Induced Differential Cross-Regulation of TLR Signaling
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- Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes.
- Dorsal Root Ganglia Sensory Neuronal Cultures: a tool for drug discovery for peripheral neuropathies
- Generation of somatic sensory neuron diversity and implications on sensory coding
- MicroRNA-146a is Linked to Pain-related Pathophysiology of Osteoarthritis
- Quantitation of Microvascular Plasma Perfusion and Neuronal Microtubule-Associated Protein in Ischemic Mouse Brain by Laser-Scanning Confocal Microscopy
- Making the pain connection.
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- MicroRNAs and Diabetic Complications
- Matrix Metalloproteinase 2 (MMP2) and MMP9 Secreted by Erythropoietin-Activated Endothelial Cells Promote Neural Progenitor Cell Migration
- Phosphodiesterase-5 (PDE5) is a Therapeutic Target for Peripheral Neuropathy in Diabetic Mice
- NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
- Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db−/db− mouse, a type 2 diabetes model
- Morphometry of dorsal root ganglion in chronic experimental diabetic neuropathy.
- MicroRNA Expression and Identification of Putative miRNA Targets in Ovarian Cancer
Cited by
- MicroRNA-146a-5p attenuates neuropathic pain via suppressing TRAF6 signaling in the spinal cord.
- Epigenetic regulation of persistent pain
- MiR-21 and miR-222 inhibit apoptosis of adult dorsal root ganglion neurons by repressing TIMP3 following sciatic nerve injury.
- Deregulation of NF-кB–miR-146a negative feedback loop may be involved in the pathogenesis of diabetic neuropathy
- Circulating microRNAs and diabetes: potential applications in medical practice
- Emerging roles of microRNAs in chronic pain.
- Current research progress of microRNA in diabetes mellitus and diabetes-associated complications
- MicroRNA transport in cardiovascular complication of diabetes.
- MicroRNA-146a and its adapter proteins are affected by diabetes in rat’s heart
- Non-coding RNAs as Emerging Regulators of Neural Injury Responses and Regeneration
- Evidence for Epigenetic Regulation of Gene Expression and Function in Chronic Experimental Diabetic Neuropathy
- microRNA and Pain.
- MicroRNA 146a locally mediates distal axonal growth of dorsal root ganglia neurons under high glucose and sildenafil conditions
- The role of miR-146a on NF-κB expression level in human umbilical vein endothelial cells under hyperglycemic condition
- microRNA profiling in atherosclerosis, diabetes, and migraine
- Recent advances in exploring the genetic susceptibility to diabetic neuropathy.
- MicroRNA-146a Contributes to SCI Recovery via Regulating TRAF6 and IRAK1 Expression
- MiR-29c/PRKCI Regulates Axonal Growth of Dorsal Root Ganglia Neurons Under Hyperglycemia
- PDE5 inhibitors promote recovery of peripheral neuropathy in diabetic mice
- Noncoding RNAs and Their Potential Therapeutic Applications in Tissue Engineering
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