MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.
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Summary
This chapter focuses on the important discovery that virus-specific cytotoxic T cells are dually specific for virus and for a self cell surface antigen encoded by the major histocompatibility complex (MHC).
- Type
- review
- Published
- 1979-01-01
- Cited by
- 1,880
- References
- 612
- OpenAlex
- https://openalex.org/W40843633
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27300215
Keywords
Biology, Cytotoxic T cell, Antigen, Major histocompatibility complex, Immunology
References
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- Functional and structural considerations in the recognition of virus-infected cells by cytotoxic T lymphocytes.
- Major transplantation antigens, viruses, and specificity of surveillance T cells.
- Natural History of Infectious Disease
- Cell-mediated immunity and the major histocompatibility complex.
- The concept of autoimmune liver disease.
- Significance of the major histocompatibility complex as assessed by T-cell-mediated lympholysis involving syngeneic stimulating cells.
- Cloned T-cell lines with specific cytolytic activity.
- Antigen-binding, idiotypic T-lymphocyte receptors.
- Primary in vitro sensitization of virus specific cytotoxic T lymphocytes.
- Regulation of the immune response by T-cell subclasses.
Cited by
- Increased frequency of T cell receptor V alpha 12.1 expression on CD8+ T cells: evidence that V alpha participates in shaping the peripheral T cell repertoire [published erratum appears in J Exp Med 1991 Nov 1;174(5):following 1286]
- Evolution ofMHC polymorphism: Extensive sharing of polymorphic sequence motifs between human and bovine DRB alleles
- The human thymic microenvironment: thymic epithelium contains specific keratins associated with early and late stages of epidermal keratinocyte maturation.
- Fine dissection of a nine amino acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class I-restricted H-2Db cytotoxic T lymphocytes
- Cytotoxic T lymphocyte control of acute lymphocytic choriomeningitis virus infection: interferon gamma, but not tumour necrosis factor alpha, displays antiviral activity in vivo.
- Listeria monocytogenes-reactive T lymphocyte clones with cytolytic activity against infected target cells
- Identification of an alternatively spliced Kd and the Qa-6d mRNAs by using amplified cDNA.
- Defective expression of MHC class I antigens is frequent in B‐cell lymphomas of high‐grade malignancy
- Some problem areas in the interaction between viruses and the immune system
- Towards a logical analysis of the immune response.
- Which T cells are relevant to resistance against Listeria monocytogenes infection?
- Specific selection of host cell glycoproteins during assembly of murine leukaemia virus and vesicular stomatitis virus: presence of Thy-1 glycoprotein and absence of H-2, Pgp-1 and T-200 glycoproteins on the envelopes of these virus particles.
- Target-cell recognition by cloned lines of influenza virus-specific cytotoxic T lymphocytes. Selective inhibition by a monoclonal H-2-specific antibody
- Expression of complete transplantation antigens by mammalian cells transformed with truncated class I genes
- Downregulation of peptide transporter genes in cell lines transformed with the highly oncogenic adenovirus 12
- A combined approach for quantitation of each specific HLA-A or -B antigen expressed on cells.
- Significance of the six peptide-binding pockets of HLA-A2.1 in influenza A matrix peptide-specific cytotoxic T-lymphocyte reactivity.
- HLA expression in hepatocellular carcinoma cell lines
- Natural history of HLA expression during tumour development.
- Affinity Maturation of Lymphocyte Receptors and Positive Selection of T Cells in the Thymus
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