Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
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Summary
It is shown that ubiquitinated DRiPs are formed from human immunodeficiency virus Gag polyprotein, a long-lived viral protein that serves as a source of antigenic peptides.
- Type
- article
- Published
- 2000-04-13
- Cited by
- 1,691
- References
- 35
- OpenAlex
- https://openalex.org/W1782287000
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205005795
Keywords
Endoplasmic reticulum, MHC class I, Proteasome, Ubiquitin, Ribosome
References
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- MHC Ligands and Peptide Motifs
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- Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
- LEAFY expression and flower initiation in Arabidopsis.
- Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?
- Control of flower development in Arabidopsis thaliana by APETALA1 and interacting genes
- Distinct mechanisms promote polarity establishment in carpels of Arabidopsis.
- ‘Pod shatter’ in Arabidopsis thalianaBrassica napus and B. juncea
- Specific expression of the AGL1 MADS-box gene suggests regulatory functions in Arabidopsis gynoecium and ovule development.
- The major substrates for TAP in vivo are derived from newly synthesized proteins
- Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules.
- Production and characterization of monoclonal antibodies specific to multi‐ubiquitin chains of polyubiquitinated proteins
- The protein encoded by the Arabidopsis homeotic gene agamous resembles transcription factors
- AGL1-AGL6, an Arabidopsis gene family with similarity to floral homeotic and transcription factor genes.
- Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
- Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex.
- Association of class I major histocompatibility heavy and light chains induced by viral peptides
Cited by
- Endoplasmic reticulum stress in brain damage.
- Cellular stress and protein misfolding during aging.
- Intramembrane proteolysis by the aspartic protease SPP
- Compartment-specific functions of the ubiquitin-proteasome pathway.
- An integrated view of the roles and mechanisms of heat shock protein gp96-peptide complex in eliciting immune response.
- The importance of trimming reactions on asparagine-linked oligosaccharides for protein quality control
- Quality control in the endoplasmic reticulum
- The role of idiotype-specific immunity in antigen receptor diversity
- Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII
- A Cure for Traffic Jams: Small Molecule Chaperones in the Endoplasmic Reticulum
- HFE cross-talks with the MHC class I antigen presentation pathway.
- Viral evasion of the MHC class I antigen-processing machinery
- Interferon‐γ, the functional plasticity of the ubiquitin–proteasome system, and MHC class I antigen processing
- The ubiquitin-proteasome system: focus on the heart.
- Microarrays and the relationship of mRNA variation to protein variation during the cell cycle.
- Protein quality control: the who’s who, the where’s and therapeutic escapes
- Parkinson's disease: genetics and beyond.
- Ribosome Association and Stability of the Nascent Polypeptide-Associated Complex Is Dependent Upon Its Own Ubiquitination
- The physiological response of the white-rot fungus, Schizophyllum commune to Trichoderma Viride, during interspecific mycelial combat
- Quality Control: Proteins and Organelles
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