Mutations in the neurofibromatosis 1 gene in sporadic malignant melanoma cell lines
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Summary
A homozygous deletion of most of NF1 is reported in one of eight malignant melanoma cell lines leading to loss of detectable mRNA and protein, as well as the apparent absence of protein and mRNA in another melanoma, which suggests that NF1 can function as a tumour suppressor gene in the development or progression of malign melanoma.
- Type
- article
- Published
- 1993-02-01
- Cited by
- 143
- References
- 38
- OpenAlex
- https://openalex.org/W1995259219
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24093669
Keywords
Neurofibromin 1, Biology, Neurofibromatosis, Melanoma, Cancer research
References
- A clinical, pathological, and genetic study of multiple neurofibromatosis
- Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma.
- Antibodies: A Laboratory Manual
- Cell-mediated cytotoxicity for bladder carcinoma: evaluation of a workshop.
- The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes.
- A de novo Alu insertion results in neurofibromatosis type 1
- The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.
- Loss of polymorphic restriction fragments in malignant melanoma: implications for tumor heterogeneity.
- Loss of alleles from the distal short arm of chromosome 1 occurs late in melanoma tumor progression.
- Melanin macroglobules as a cellular marker of neurofibromatosis: a quantitative study.
- A genetic model for colorectal tumorigenesis.
- Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients
- The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21.
- Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter.
- Identification and characterization of the neurofibromatosis type 1 protein product.
- Neurofibromatosis: Phenotype, Natural History and Pathogenesis
- Transforming ras genes from human melanoma: a manifestation of tumour heterogeneity?
- Structural rearrangement of the retinoblastoma gene in human breast carcinoma.
- cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product.
- A 90 kb DNA deletion associated with neurofibromatosis type 1.
Cited by
- Suppression of ras oncogene-mediated transformation.
- Intrinsic and GTPase-activating protein-stimulated Ras GTPase assays.
- Specific expression of the neurofibromatosis type 1 gene (NF1) in the hamster Schwann cell.
- Loss of neurofibromatosis type I (NFI) gene expression in pheochromocytomas from patients without NFI
- Conception d'inhibiteurs du domaine SH3 de la protéine RasGAP à activité anti-tumorale potentielle
- The NF1 gene revisited – from bench to bedside
- Deletions spanning the neurofibromatosis 1 gene: identification and phenotype of five patients.
- Tumor suppressor genes and human cancer.
- Increasing complexity of Ras signal transduction: involvement of Rho family proteins.
- Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function
- Genomic Classification of Cutaneous Melanoma
- Neurofibromatosis type 1 I. General overview
- Comparison of insertion rate of L1 retroposon into intron 30 of the neurofibromatosis type 1 gene in seven Asian and Pacific populations
- C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.
- Neurofibromatosis type 1: report of two contrasting cases.
- Urinary bladder transitional cell carcinogenesis is associated with down-regulation of NF1 tumor suppressor gene in vivo and in vitro.
- A novel insertional mutation of a single base in exon 34 of the neurofibromatosis‐1 gene
- Neurofibromatosis: chronological history and current issues
- p53 mutation as the second event in juvenile chronic myelogenous leukemia in a patient with neurofibromatosis type 1
- Microdeletions and molecular genetics
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