Damage control: management of cellular stress by the NLRP3 inflammasome

Keywords

Inflammasome, Proinflammatory cytokine, Pyroptosis, Cell biology, DNA damage

References

• The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cellsGinevra Licandro, Hwei Ling Khor, Ottavio Beretta — 2013
• IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formationMohammad Hasan Zaki, Peter Vogel, Mathilde Body–Malapel — 2010
• ASC is a Bax adaptor and regulates the p53–Bax mitochondrial apoptosis pathwayTakao Ohtsuka, Hoon Ryu, Yoji Andrew Minamishima — 2004
• Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentrationVirginie Pétrilli, Stéphanie Papin, Catherine Dostert — 2007
• Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3Thirumala‐Devi Kanneganti, Nesrin Özören, Mathilde Body–Malapel — 2006
• The rhapsody of NLRPs: master players of inflammation … and a lot moreLia Paola Zambetti, Federica Laudisi, Ginevra Licandro — 2012
• Gout-associated uric acid crystals activate the NALP3 inflammasomeFabio Martinon, Virginie Pétrilli, Annick Mayor — 2006
• IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation.Britta Siegmund, Hans-Anton Lehr, Giamila Fantuzzi — 2001
• Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases.Jeremy Dupaul-Chicoine, Garabet Yeretssian, Karine Doiron — 2010
• The Caspase-1 Digestome Identifies the Glycolysis Pathway as a Target during Infection and Septic Shock*♦Wei Shao, Garabet Yeretssian, Karine Doiron — 2007
• Critical role for calcium mobilization in activation of the NLRP3 inflammasomeTomohiko Murakami, Johan Öckinger, Jiujiu Yu — 2012
• Mechanism of Action of CamptothecinLeroy F. Liu, Pu Duann, Ching‐Tai Lin — 1996
• p53 mutations in human cancers.Monica Hollstein, David Sidransky, Bert Vogelstein — 1991
• NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?Jürg Tschopp, Kate Schroder — 2010
• Inflammasomes in health and diseaseTill Strowig, Jorge Henao‐Mejia, Eran Elinav — 2012
• The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancerIrving C. Allen, Erin McElvania, Rita-Marie T. Woodford — 2010
• The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitisHasan Zaki, Kelli L. Boyd, Peter Vogel — 2010
• Cryopyrin activates the inflammasome in response to toxins and ATPSanjeev Mariathasan, David S. Weiss, Kim Newton — 2006
• Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability.Francesco Colotta, Paola Allavena, Antonio Sica — 2009
• Synergism of NOD2 and NLRP3 activators promotes a unique transcriptional profile in murine dendritic cellsCristina Conforti‐Andreoni, Ottavio Beretta, Ginevra Licandro — 2010

Cited by

• Cell Death Pathways: a Novel Therapeutic Approach for NeuroscientistsSilvia Egea Ruiz, Julia Moltó Berenguer, Juan A. Conesa — 2017
• The immediate protective response to microbial challengeJosé M. González‐Navajas, Mary Corr, Eyal Raz — 2014
• Chronic allograft dysfunction: a model disorder of innate immunity.W. Land — 2013
• LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis.Zhenfeng Ding, Shuang Liu, Xianwei Wang — 2014
• Autophagy Inhibition Contributes to ROS-Producing NLRP3-Dependent Inflammasome Activation and Cytokine Secretion in High Glucose-Induced MacrophagesJiezhi Dai, Xiaotian Zhang, Li Li — 2017
• Rapamycin Attenuates High Glucose-Induced Inflammation Through Modulation of mTOR/NF-κB Pathways in MacrophagesJiezhi Dai, Chaoyin Jiang, Hua Chen — 2019
• Host-induced spermidine production in motile Pseudomonas aeruginosa triggers phagocytic uptakeSebastian Felgner, Matthias Preuße, Ulrike Beutling — 2020
• NLRP3 inflammasome inhibitor MCC950 can reduce the damage of pancreatic and intestinal barrier function in mice with acute pancreatitisYanghui Shen, Huobao Yang, Dansen Wu — 2022
• NLRP3 proteins translocation into nuclei mediates SV40 T-antigen-induced corneal epithelial cell immortalization.Jie Xu, Changkai Jia, Qiao‐Cheng Qiu — 2025
• Genetic and biomechanics insights into cathepsins and non-cancerous digestive diseases: A bidirectional two-sample Mendelian randomization studyRuiming Ou, Shengping Hu, Yu Liu — 2025
• Necrobiology of Liver Cancer: Autophagy and Cellular SenescenceA. Zimmermann — 2016

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