Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability.
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Summary
This work surmises that CRI represents the seventh hallmark of cancer, and suggests that an additional mechanism involved in cancer-related inflammation (CRI) is induction of genetic instability by inflammatory mediators, leading to accumulation of random genetic alterations in cancer cells.
- Type
- review
- Published
- 2009-07-01
- Cited by
- 2,872
- References
- 204
- Access
- Open access
- OpenAlex
- https://openalex.org/W2102144390
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9314391
Keywords
Inflammation, Cancer, Angiogenesis, Cancer research, Tumor microenvironment
References
- Misregulation of Stromelysin-1 Expression in Mouse Mammary Tumor Cells Accompanies Acquisition of Stromelysin-1-dependent Invasive Properties*
- TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.
- Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation.
- Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
- Chromosomal instability is associated with higher expression of genes implicated in epithelial-mesenchymal transition, cancer invasiveness, and metastasis and with lower expression of genes involved in cell cycle checkpoints, DNA repair, and chromatin maintenance.
- Tumour-educated macrophages promote tumour progression and metastasis
- Neoplastic progression in ulcerative colitis: histology, DNA content, and loss of a p53 allele.
- Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts
- Breast cancer expression of CD163, a macrophage scavenger receptor, is related to early distant recurrence and reduced patient survival
- Oxidative stress increases frameshift mutations in human colorectal cancer cells.
- Interdependent roles for hypoxia inducible factor and nuclear factor‐κB in hypoxic inflammation
- Host-Derived Interleukin-1α Is Important in Determining the Immunogenicity of 3-Methylcholantrene Tumor Cells1
- Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway1
- Tumor-microenvironment interactions: dangerous liaisons.
- Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis
- Nitric oxide induces conformational and functional modifications of wild-type p53 tumor suppressor protein.
- Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis.
- Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1.
- Oxidative Stress Regulates Expression of VEGFR1 in Myeloid Cells: Link to Tumor-Induced Immune Suppression in Renal Cell Carcinoma1
- Interleukin 1-induced augmentation of experimental metastases from a human melanoma in nude mice.
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- Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell‐specific localization of active viral and oncogenic signaling proteins
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- A functional module-based exploration between inflammation and cancer in esophagus
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- High salt induces anti-inflammatory MΦ2-like phenotype in peripheral macrophages
- Vascular hyperpermeability as a hallmark of phacomatoses: is the etiology angiogenesis comparable with mechanisms seen in inflammatory pathways? Part I: historical observations and clinical perspectives on the etiology of increased CSF protein levels, CSF clotting, and communicating hydrocephalus: a
- High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors
- Prognostic efficacy of inflammation-based markers in patients with curative colorectal cancer resection
- The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages
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