Emerging Strategies to Enhance Homing and Engraftment of Hematopoietic Stem Cells
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Summary
This review will present emerging strategies based on ex vivo manipulation of graft HSCs that are aimed at enhancing the responsiveness of H SCs to BM-secreted chemoattractants and/or promoting HSC adhesion and seeding efficiency in the BM microenvironment.
- Type
- review
- Published
- 2015-09-24
- Cited by
- 91
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W1933705776
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18921986
Keywords
Homing (biology), Stem cell, Haematopoiesis, Cell biology, CXCR4
References
- Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient.
- Mild heat treatment primes human CD34+ cord blood cells for migration towards SDF-1α and enhances engraftment in an NSG mouse model
- Pulse exposure of haematopoietic grafts to prostaglandin E2 in vitro facilitates engraftment and recovery
- Advances in umbilical cord blood stem cell expansion and clinical translation.
- Enhancing hematopoietic stem cell transplantation efficacy by mitigating oxygen shock
- Enhancing engraftment of cord blood cells via insight into biology of stem/progenitor cell function
- CONDITIONING FOR HEMATOPOIETIC TRANSPLANTATION ACTIVATES THE COMPLEMENT CASCADE AND INDUCES A PROTEOLYTIC ENVIRONMENT IN BONE MARROW – A NOVEL ROLE FOR BIOACTIVE LIPIDS AND SOLUBLE C5b-C9 AS HOMING FACTORS
- The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration.
- A novel view of the adult bone marrow stem cell hierarchy and stem cell trafficking
- The endosteal ‘osteoblastic’ niche and its role in hematopoietic stem cell homing and mobilization
- Regulation of inflammation by extracellular acidification and proton-sensing GPCRs.
- Transient inhibition of GSK-3β promotes early and late engraftment of ex vivo expanded haematopoietic progenitor cells in immuno-compromised mice
- PLASMA SPHINGOSINE 1-PHOSPHATE IS A MAJOR CHEMOATTRACTANT THAT DIRECTS EGRESS OF HEMATOPOIETIC STEM PROGENITOR CELLS FROM BONE MARROW AND ITS LEVEL IN PERIPHERAL BLOOD INCREASES DURING MOBILIZATION DUE TO ACTIVATION OF COMPLEMENT CASCADE/MEMBRANE ATTACK COMPLEX
- DEFECTIVE ENGRAFTMENT OF C3aR-/- HEMATOPOIETIC STEM PROGENITOR CELLS REVEALS A NOVEL ROLE OF THE C3a-C3aR AXIS IN BONE MARROW HOMING
- The basic structure and dynamics of cell membranes: an update of the Singer-Nicolson model.
- Advances in umbilical cord blood manipulation—from niche to bedside
- Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment.
- Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor
- Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice.
- Cord blood transplantation: state of the art
Cited by
- Early assessment of dosimetric and biological differences of total marrow irradiation versus total body irradiation in rodents
- Enhancing human cord blood hematopoietic stem cell engraftment by targeting nuclear hormone receptors
- Mobilized Peripheral Blood versus Cord Blood: Insight into the Distinct Role of Proinflammatory Cytokines on Survival, Clonogenic Ability, and Migration of CD34+ Cells
- Ceramide and S1P signaling in embryonic stem cell differentiation
- High Level P2X7-Mediated Signaling Impairs Function of Hematopoietic Stem/Progenitor Cells
- POOR MOBILIZATION IN T CELL-DEFICIENT NUDE MICE IS EXPLAINED BY DEFECTVE ACTIVATION OF GRANULOCYTES AND MONOCYTES
- Inducible Nitric Oxide Synthase (iNOS) Is a Novel Negative Regulator of Hematopoietic Stem/Progenitor Cell Trafficking
- Effect of colorectal cancer on the number of normal stem cells circulating in peripheral blood.
- LCN2 overexpression in bone enhances the hematopoietic compartment via modulation of the bone marrow microenvironment
- Hematopoietic stem cells under pressure
- Leveraging Stem Cell Homing for Therapeutic Regeneration
- Stem cells and their potential clinical applications in psychiatric disorders
- Prostaglandin E2 promotes human CD34+ cells homing through EP2 and EP4 in vitro
- Induced Cell Turnover: A Novel Therapeutic Modality for In Situ Tissue Regeneration
- Administration of signalling molecules dictates stem cell homing for in situ regeneration
- Not all stem cells are equally great: donor single-nucleotide polymorphisms (SNP) may matter more than previously thought
- Rescuing Self: Transient Isolation and Autologous Transplantation of Bone Marrow Mitigates Radiation-Induced Hematopoietic Syndrome and Mortality in Mice
- Mammalian sterile 20 kinase 1 and 2 are important regulators of hematopoietic stem cells in stress condition
- Recent Progress in Stem Cell Modification for Cardiac Regeneration
- Biomaterials for endogenous regenerative medicine: Coaxing stem cell homing and beyond
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