Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop
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Summary
It is demonstrated that the specific amino acids in the V3 loop of the HIV-1 envelope protein that determine cellular tropism also regulate chemokine coreceptor preference for cell entry by the virus.
- Type
- article
- Published
- 1997-09-01
- Cited by
- 302
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W1923928177
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39637526
Keywords
Biology, V3 loop, Chemokine receptor, Tropism, CXCR4
References
- Differences in CD4 dependence for infectivity of laboratory-adapted and primary patient isolates of human immunodeficiency virus type 1
- HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor
- Mapping of independent V3 envelope determinants of human immunodeficiency virus type 1 macrophage tropism and syncytium formation in lymphocytes
- Evidence that the structural conformation of envelope gp120 affects human immunodeficiency virus type 1 infectivity, host range, and syncytium-forming ability
- The region of the envelope gene of human immunodeficiency virus type 1 responsible for determination of cell tropism
- Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: analysis by single amino acid substitution
- Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
- Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population
- Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates
- Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule
- In vivo distribution and cytopathology of variants of human immunodeficiency virus type 1 showing restricted sequence variability in the V3 loop
- Identification of human immunodeficiency virus envelope gene sequences influencing viral entry into CD4-positive HeLa cells, T-leukemia cells, and macrophages
- A single amino acid substitution in the V1 loop of human immunodeficiency virus type 1 gp120 alters cellular tropism
- Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: definition of critical amino acids involved in cell tropism
- Identification of a major co-receptor for primary isolates of HIV-1
- HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
- Human immunodeficiency virus envelope V1 and V2 regions influence replication efficiency in macrophages by affecting virus spread.
- The role of viral diversity in HIV pathogenesis.
- Single amino-acid changes in HIV envelope affect viral tropism and receptor binding
- Multiple Extracellular Elements of CCR5 and HIV-1 Entry: Dissociation from Response to Chemokines
Cited by
- Fine definition of a conserved CCR5-binding region on the human immunodeficiency virus type 1 glycoprotein 120.
- Viral exploitation and subversion of the immune system through chemokine mimicry
- Simian immunodeficiency virus encephalitis: analysis of envelope sequences from individual brain multinucleated giant cells and tissue samples.
- Identification of Conserved and Variable Structures in the Human Immunodeficiency Virus gp120 Glycoprotein of Importance for CXCR4 Binding
- HIV‐1 fitness and macrophages
- Inhibition of Coreceptor-Independent Cell-to-Cell Human Immunodeficiency Virus Type 1 Transmission by a CD4-Immunoglobulin G2 Fusion Protein
- Nucleotide and amino acid mutations in human immunodeficiency virus corresponding to CD4+ decline
- A killer mimotope with therapeutic activity against AIDS-related opportunistic micro-organisms inhibits ex-vivo HIV-1 replication
- Broad usage spectrum of G protein-coupled receptors as coreceptors by primary isolates of HIV.
- How does HIV-1 infect a susceptible human cell?: Current thinking.
- Cell surface receptors for gammaretroviruses.
- HIV Coreceptors and Chemokines as Therapeutic Targets Against HIV/AIDS
- Fusion mediated by the HIV-1 envelope protein.
- Structural and Functional Analysis of HIV-1 Coreceptors: Roles of Charged Residues and Posttranslational Modifications on Coreceptor Activity
- Characterization and Enhanced Processing of Soluble, Oligomeric gp140 Envelope Glycoproteins Derived from Human Immunodeficiency Virus Type-1 Primary Isolates
- Characterisation of the HIV-1 subtype C Env gene and the expression of the Env protein from selected isolates in mammalian cells
- Conformationally Restricted Synthetic AIDS Vaccine
- Fusion of Biological Membranes and Related Problems
- L'impact de la grossesse sur l'amplitude et la diversité de la reconnaissance antigénique des lymphocytes T cytotoxiques dirigés contre le VIH-1
- Characterisation of α4β7and DC-SIGN reactivity of HIV-1 subtype C transmitted founder variants compared with chronic infection controls
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