Endogenous molecular network reveals two mechanisms of heterogeneity within gastric cancer
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Summary
An endogenous molecular network is constructed of GC that can be expanded in the future and would broaden the known mechanisms of intratumor heterogeneity and demonstrate that four positive feedback loops in the network are critical for GC cell phenotypes.
- Type
- article
- Published
- 2015-04-23
- Cited by
- 40
- References
- 117
- Access
- Open access
- OpenAlex
- https://openalex.org/W1917704994
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2630408
Keywords
Phenotype, Cancer, Biology, Endogeny, Heterogeneous network
References
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- Epidemiology of Stomach Cancer
- Cell surface properties of B16 melanoma variants with differing metastatic potential.
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- Robustness in bacterial chemotaxis
- Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor.
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- GENERIC ENZYMATIC RATE EQUATION UNDER LIVING CONDITIONS
- Frequent somatic mutations of the beta-catenin gene in intestinal-type gastric cancer.
- Ultrasensitivity Part I: Michaelian responses and zero-order ultrasensitivity
- In silico models of cancer
- The clonal evolution of tumor cell populations.
Cited by
- Detecting Antigen-Specific T Cell Responses: From Bulk Populations to Single Cells
- GNA13 as a prognostic factor and mediator of gastric cancer progression
- From molecular interaction to acute promyelocytic leukemia: Calculating leukemogenesis and remission from endogenous molecular-cellular network
- Synonymous mutations in oncogenesis and apoptosis versus survival unveiled by network modeling
- Coupling CDH17 and CLDN18 markers for comprehensive membrane-targeted detection of human gastric cancer
- Potential landscape of high dimensional nonlinear stochastic dynamics with large noise
- Correction: Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity.
- Cancer as robust intrinsic state shaped by evolution: a key issues review
- Novel Insights into Gastric Cancer: Methylation of R-spondins and Regulation of LGR5 by SP1
- Luteolin suppresses gastric cancer progression by reversing epithelial-mesenchymal transition via suppression of the Notch signaling pathway
- Interrogating the topological robustness of gene regulatory circuits by randomization
- Mathematical models of cell phenotype regulation and reprogramming: Make cancer cells sensitive again!
- Decoding early myelopoiesis from dynamics of core endogenous network
- Coarse-grained endogenous network predicts main dynamical sequences in myeloid differentiation and trans-differentiation
- Evolutionary Origins of Cancer Driver Genes and Implications for Cancer Prognosis
- SDE decomposition and A-type stochastic interpretation in nonequilibrium processes
- Beyond cancer genes: colorectal cancer as robust intrinsic states formed by molecular interactions
- Endogenous Molecular-Cellular Network Cancer Theory: A Systems Biology Approach.
- Genetic features of multicentric/multifocal intramucosal gastric carcinoma
- A landscape view on the interplay between EMT and cancer metastasis
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