Mutagen sensitivity and suppression of position‐effect variegation result from mutations in mus209, the Drosophila gene encoding PCNA.
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Summary
All three ts mutants strongly suppress PEV, which suggests a role for PCNA in chromatin assembly or modification, and temperature shift studies reveal that the vital function of PCNA is required throughout virtually all stages of fly development, and that maternally encodedPCNA is essential for embryogenesis.
- Type
- article
- Published
- 1994-03-01
- Cited by
- 140
- References
- 8
- Access
- Open access
- OpenAlex
- https://openalex.org/W1908345703
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23939706
Keywords
Biology, Genetics
References
Cited by
- Chromosomes and expression mechanisms
- Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin.
- dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila.
- DNA repair defects and other (mus)takes in Drosophila melanogaster.
- Spontaneous and bleomycin-induced genomic alterations in the progeny of Drosophila treated males depends on the Msh2 status. DNA fingerprinting analysis.
- Effects of deranged metabolism on epigenetic changes in cancer
- Polytene chromosomes, heterochromatin, and position effect variegation.
- Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control.
- DNA polymerase delta, an essential enzyme for DNA transactions.
- Chromatin remodeling factors and DNA replication.
- Investigation of the molecular basis of three new disorders of brain growth and development identified amongst the Amish
- Chromatin structure and the regulation of gene expression: the lessons of PEV in Drosophila.
- PCNA connects DNA replication to epigenetic inheritance in yeast
- Proliferating cell nuclear antigen: More than a clamp for DNA polymerases
- Site-specific mutagenesis of Drosophila proliferating cell nuclear antigen enhances its effects on calf thymus DNA polymerase δ
- Psf2 plays important roles in normal eye development in Xenopus laevis
- A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae.
- CAF-1 and the inheritance of chromatin states: at the crossroads of DNA replication and repair.
- Mutual correction of faulty PCNA subunits in temperature-sensitive lethal mus209 mutants of Drosophila melanogaster.
- The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci
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