Two separate defects, affecting true naïve (TNa) or virtual memory (VM) T cell precursors, combine to reduce naïve T cell responses with aging
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Summary
TCR is identified as the key factor in differential maintenance and function of Ag-specific precursors in unimmunized mice with aging, and it is found that VM conversion had adverse functional effects in both old wild-type and old TCRTg mice; that is, old VM, but not old true naive, T cells exhibited blunted TCR-mediated, butNot IL-15–mediated, proliferation.
- Type
- article
- Published
- 2013-11-29
- Cited by
- 104
- References
- 44
- Access
- Open access
- OpenAlex
- https://openalex.org/W1907611471
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4965860
Keywords
T-cell receptor, Memory T cell, T cell, Biology, Naive T cell
References
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- Innate and virtual memory T cells in man
- Naïve T cell maintenance and function in human aging
- Aging of the T cell compartment in mice and humans: from no naïve expectations to foggy memories
- Reduced naïve CD8+ T‐cell priming efficacy in elderly adults
- T cell memory: The effect of ageing on CD8+ T cells
- CD8+ T Cell Exhaustion, Suppressed Gamma Interferon Production, and Delayed Memory Response Induced by Chronic Brucella melitensis Infection
- Characterization of age‐associated exhausted CD8+ T cells defined by increased expression of Tim‐3 and PD‐1
- Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+ T cells in aged mice
- Preventing thymus involution in K5.Cyclin D1 transgenic mice sustains the naïve T cell compartment with age (LYM6P.716)
- NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs.
- Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner
- Attrition of memory CD8 T cells during sepsis requires LFA‐1
- Heterochronic Parabiosis Studies of the Aging Immune System
- Memory CD8+ T Cells: Orchestrators and Key Players of Innate Immunity?
- Dysregulated TGF-β Production Underlies the Age-Related Vulnerability to Chikungunya Virus
- Identification de nouveaux biomarqueurs permettant la caractérisation des lymphocytes T CD8 mémoires innés
- CD4+ Virtual Memory: Antigen-inexperienced T cells reside in the naïve, regulatory, and memory T cell compartments at similar frequencies, implications for autoimmunity
- Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection
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