Wnt signalling: What The X@# is WTX?
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Summary
It is demonstrated that Amer1/WTX, a tumour suppressor protein previously known for promoting β‐catenin degradation and thus antagonizing Wnt signalling, is also required for LRP6 receptor phosphorylation and therefore activation of Wnt signaling.
- Type
- letter
- Published
- 2011-04-20
- Cited by
- 16
- References
- 17
- Access
- Open access
- OpenAlex
- https://openalex.org/W1907096963
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5613086
Keywords
Biology, Wnt signaling pathway, Genetics, Signal transduction
References
- Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions
- A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling.
- Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis
- A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
- Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction
- Two novel WTX mutations underscore the unpredictability of male survival in osteopathia striata with cranial sclerosis
- Dynamic recruitment of axin by Dishevelled protein assemblies
- Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation
- A mechanism for Wnt coreceptor activation.
- An X Chromosome Gene, WTX, Is Commonly Inactivated in Wilms Tumor
- AMER1 regulates the distribution of the tumor suppressor APC between microtubules and the plasma membrane
- Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.
- Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation
- Wnt/β-catenin signaling: components, mechanisms, and diseases
- Amer1/WTX couples Wnt‐induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation
Cited by
- R-spondin1 Deficiency Enhances &bgr;-Cell Neogenesis in a Murine Model of Diabetes
- Cross-talk between Wnt/β-catenin and Hippo signaling pathways: a brief review
- Wnt/β-catenin signaling and disease.
- Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling.
- APC protein immunoexpression in colorectal adenoma and adenocarcinoma
- Merlin inhibits Wnt/β-catenin signaling by blocking LRP6 phosphorylation
- Wnt Signaling in Skin Development, Homeostasis,
- Novel APC gene mutations associated with protein alteration in diffuse type gastric cancer
- Complexity of the Wnt/β‑catenin pathway: Searching for an activation model.
- Diffuse Gastric Cancer: A Summary of Analogous Contributing Factors for Its Molecular Pathogenicity
- Zebrafish Wtx is a negative regulator of Wnt signaling but is dispensable for embryonic development and organ homeostasis
- Mutational screening through comprehensive bioinformatics analysis to detect novel germline mutations in the APC gene in patients with familial adenomatous polyposis (FAP)
- Expression of Parkin, APC, APE1, and Bcl-xL in Colorectal Polyps
- amer1 Regulates Zebrafish Craniofacial Development by Interacting with the Wnt/β-Catenin Pathway
- The Wnt/β-Catenin Pathway
- JCOL Vol 33 Ed 03-Arquivo-livro.indb
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