p53 gene mutations, p53 protein accumulation and compartmentalization in colorectal adenocarcinoma.
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Summary
The data suggest that mechanisms other than mutations may also play a role in inhibiting p53 tumor-suppressing functions in colorectal carcinomas.
- Type
- article
- Published
- 1995-09-01
- Cited by
- 168
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W1906462579
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30712403
Keywords
Biology, Gene mutation, Gene, Mutation, Cytoplasm
References
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- Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.
- Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.
- p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.
- p53 protein accumulation detected by five different antibodies: relationship to prognosis and heat shock protein 70 in breast cancer.
- Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.
- Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer.
- Accumulation of wild type p53 protein in human astrocytomas.
- Heterogeneity of subcellular localization of p53 protein in human glioblastomas.
- p53 gene mutations and protein accumulation in human ovarian cancer.
- Increased p53 protein content of colorectal tumours correlates with poor survival.
- Formation of stable p53 homotetramers and multiples of tetramers
- Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.
- Cytoplasmic accumulation of p53 protein: an independent prognostic indicator in colorectal adenocarcinomas.
- Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations.
- p53 function and dysfunction.
- WAF1, a potential mediator of p53 tumor suppression.
Cited by
- Electrophilic Prostaglandins and Lipid Aldehydes Repress Redox-sensitive Transcription Factors p53 and Hypoxia-inducible Factor by Impairing the Selenoprotein Thioredoxin Reductase*
- Parc: a cytoplasmic anchor for p53.
- The mitochondrial pathways of apoptosis.
- p53 and DCC immunohistochemistry in curative rectal cancer surgery
- Mutations and allelic loss of p53 in primary tumor DNA from potentially cured patients with colorectal carcinoma.
- Contribution of the DNA binding domain of p53 to regulation of its stability
- Prognostic significance of TP53 gene mutation in 995 cases of colorectal carcinoma. Influence of tumour site, stage, adjuvant chemotherapy and type of mutation.
- Function of the anterior gradient protein family in cancer
- The Role of Chk1 Kinase in Cell Cycle Checkpoint Response in Breast Epithelial Cells
- p53‐Associated Parkin‐like cytoplasmic protein (Parc) short‐interfering RNA (siRNA) alters p53 location and biology of Peyronie’s disease fibroblasts
- Comparative study of the role of serum levels of p53 antigen and its tumor cell concentration in colon cancer detection
- Regulation of p53 localization.
- Altered expression of G1 regulatory proteins in human soft tissue sarcomas.
- p53 Gene Mutation, Microsatellite Instability and Adjuvant Chemotherapy: Impact on Survival of 388 Patients with Dukes’ C Colon Carcinoma
- p53 accumulation and mutation are prognostic indicators of poor survival in human gastric carcinoma
- Conserved region mutations of the p53 gene are concentrated in distal colorectal cancers
- Expression of P53, P27 and KI‐67 in colorectal cancer patients of various ethnic origins: Clinical and tissue microarray based analysis
- Cholesterol Secosterol Aldehydes Induce Amyloidogenesis and Dysfunction of Wild Type Tumor Protein p53
- Genomic structure of karyopherin α2 (KPNA2) within a low-copy repeat on chromosome 17q23-q24 and mutation analysis in patients with Russell-Silver syndrome
- Hepcidin, a key regulator of iron metabolism, is transcriptionally activated by p53
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