Analysis of gene expression in mouse preimplantation embryos demonstrates that the primary role of enhancers is to relieve repression of promoters.

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Summary

It is proposed that the primary function of enhancers, first evident with formation of a mouse 2‐cell embryo, is to prevent repression of weak promoters, probably by altering chromatin structure.

Type
article
Published
1993-03-01
Cited by
121
References
1
Access
Open access

Keywords

Biology, Molecular biology, Genetics

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