Analysis of gene expression in mouse preimplantation embryos demonstrates that the primary role of enhancers is to relieve repression of promoters.
Explore this paper's citation graph
Summary
It is proposed that the primary function of enhancers, first evident with formation of a mouse 2‐cell embryo, is to prevent repression of weak promoters, probably by altering chromatin structure.
- Type
- article
- Published
- 1993-03-01
- Cited by
- 121
- References
- 1
- Access
- Open access
- OpenAlex
- https://openalex.org/W1905881288
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22982790
Keywords
Biology, Molecular biology, Genetics
References
Cited by
- Developmental activation of an episomic hsp70 gene promoter in two-cell mouse embryos by transcription factor Sp1.
- Quantitative analysis of luciferase activity of viral and hybrid promoters in bovine preimplantation embryos
- Localization and Differential Expression of the Krüppel-Associated Box Zinc Finger Proteins 1 and 54 in Early Mouse Development
- The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3′ processing
- Normal development and neoplasia: the imprinting connection.
- Mechanisms and control of embryonic genome activation in mammalian embryos.
- Successful DNA immunization against measles: Neutralizing antibody against either the hemagglutinin or fusion glycoprotein protects rhesus macaques without evidence of atypical measles
- A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP‐promoter complexes via heterodimeric histone fold domains.
- Reprogramming nuclei: insights from cloning, nuclear transfer and heterokaryons.
- Expression of the HSP 70.1 gene, a landmark of early zygotic activity in the mouse embryo, is restricted to the first burst of transcription.
- Dynamic alterations in the paternal epigenetic landscape following fertilization
- Regulation of zygotic gene activation in the mouse
- RNA transcript profiling during zygotic gene activation in the preimplantation mouse embryo.
- Going the distance: a current view of enhancer action.
- Rapid H1 linker histone transitions following fertilization or somatic cell nuclear transfer: evidence for a uniform developmental program in mice.
- Activation of Mouse Metallothionein-I Promoter in Mouse Preimplantation Embryos After Pronuclear Microinjection
- Zygotic gene activation and maternal factors in mammals.
- Initiation of a chromatin‐based transcriptionally repressive state in the preimplantation mouse embryo: Lack of a primary role for expression of somatic histone H1
- Potentiation of RNA polymerase II transcription by Gal4-VP16 during but not after DNA replication and chromatin assembly.
- The role of ETS transcription factors in transcription and development of mouse preimplantation embryos.
Related papers
- Cloning and Characterization of Rat BAT3 cDNA
- HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.
- Anthoxanthum Mosaic Virus
- Ecological and evolutionary importance of neighbors in the grass Anthoxanthum odoratum
- Memoirs: The Structure and Biology of Schizoneura Lanigera, Hausmann or Woolly Aphis of the Apple Tree: Part I.--The Apterous Viviparous Female
- HSV-1 strain McKrae is more neuroinvasive than HSV-1 KOS after corneal or vaginal inoculation in mice
- Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis
- Viral Pathogens and the Advantage of Sex in the Perennial Grass Anthoxanthum odoratum [and Discussion]
- Biology of Ecologically Marginal Populations of Anthoxanthum odoratum. I. Phenetics and Dynamics
- Pan-genome study of Thermococcales reveals extensive genetic diversity and genetic evidence of thermophilic adaption.