The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.
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Summary
The data identify miR-200 as a powerful marker and determining factor of the epithelial phenotype of cancer cells as well as an extraordinary marker for cells that express E-cadherin but lack expression of Vimentin.
- Type
- article
- Published
- 2008-04-01
- Cited by
- 2,356
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W1892699700
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20671097
Keywords
Biology, Sequence (biology), Gene, Repressor, Oligonucleotide
References
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- Adherens junctions and cancer.
- Adherens junction: molecular architecture and regulation.
- Myc - miR-17~92 axis blunts TGFβ signaling and production of multiple TGFβ-dependent anti-angiogenic factors
- p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
- MicroRNA-200a suppresses the Wnt/β-catenin signaling pathway by interacting with β-catenin
- Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma
- MiR-124 targets Slug to regulate epithelial–mesenchymal transition and metastasis of breast cancer
- Development of novel biomarkers in cancer: Detection of circulating miR-141 as a potential prognostic marker for prostate cancer
- The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells
- MicroRNA Expression Profiles in Kaposi’s Sarcoma
- DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer
- Transcription Factors OVOL1 and OVOL2 Induce the Mesenchymal to Epithelial Transition in Human Cancer
- Therapeutic delivery of miR-200c enhances radiosensitivity in lung cancer.
- Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer.
- Characterization of miR-888 expression and regulation in endometrial cancer
- The role of microRNAs during hepatitis C viral infection and liver regeneration
- miRNAs as prognostic and therapeutic tools in epithelial ovarian cancer.
- miRNA therapy targeting cancer stem cells: a new paradigm for cancer treatment and prevention of tumor recurrence.
- Quantifying the Landscape for Development and Cancer from a Core Cancer Stem Cell Circuit.
- MicroRNA-200 promotes lung cancer cell growth through FOG2-independent AKT activation
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