The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells.
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Summary
PP1 is identified as a serine/threonine phosphatase that associates with and dephosphorylates AKT in breast cancer cells, and it is shown that ErbB2 inhibits PP1-dependent deph phosphorylation of AKT and functions to regulate AKT kinase by simultaneously promoting its activation while inhibiting its inactivation.
- Type
- article
- Published
- 2003-11-15
- Cited by
- 97
- References
- 44
- OpenAlex
- https://openalex.org/W1886694278
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3214658
Keywords
Protein kinase B, Phosphorylation, AKT1, PI3K/AKT/mTOR pathway, Dephosphorylation
References
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Cited by
- Phase II Trial of Gemcitabine and Tanespimycin (17AAG) in Metastatic Pancreatic Cancer: A Mayo Clinic Phase II Consortium Study
- Investigation of the Hsp90 C-terminal Binding Site, Novel Inhibitors and Isoform-Dependent Client Proteins
- Progesterone and Src Family Inhibitor PP1 Synergistically Inhibit Cell Migration and Invasion of Human Basal Phenotype Breast Cancer Cells
- HER receptor-mediated dynamic signalling in breast cancer cells
- GSK3 Mediates Signaling Upstream of Akt
- Phosphatase inhibition and cell survival after DNA damage induced by radiation
- Targeting Hsp90 by 17-AAG in leukemia cells: mechanisms for synergistic and antagonistic drug combinations with arsenic trioxide and Ara-C
- Role of HER‐2/neu signaling in sensitivity to tumor necrosis factor‐related apoptosis‐inducing ligand: Enhancement of TRAIL‐mediated apoptosis by amiloride
- UIM domain-dependent recruitment of the endocytic adaptor protein Eps15 to ubiquitin-enriched endosomes
- Hsp90 Regulates the Phosphorylation and Activity of Serum- and Glucocorticoid-regulated Kinase-1*
- New cancer therapeutics: target-specific in, cytotoxics out?
- Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Trastuzumab
- BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma
- Protein Kinase C Negatively Regulates Akt Activity and Modifies UVC-induced Apoptosis in Mouse Keratinocytes*
- Downregulation of Caveolin-1 Enhances Fusion of Human BeWo Choriocarcinoma Cells
- A Small Molecule Inhibits Akt through Direct Binding to Akt and Preventing Akt Membrane Translocation*
- Elucidating Human Phosphatase-Substrate Networks
- Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells
- Freud-1/Aki1, a Novel PDK1-Interacting Protein, Functions as a Scaffold To Activate the PDK1/Akt Pathway in Epidermal Growth Factor Signaling
- In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative
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