Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2

Keywords

Protein kinase B, Biology, PI3K/AKT/mTOR pathway, Cancer research, Cyclin D

References

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• Geldanamycin, a heat shock protein 90-binding benzoquinone ansamycin, inhibits steroid-dependent translocation of the glucocorticoid receptor from the cytoplasm to the nucleus.Michael J. Czar, Mario D. Galigniana, Adam M. Silverstein — 1997
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• An immunotherapeutic approach to treatment of breast cancer: focus on trastuzumab plus paclitaxelTeresa Gilewski, Andrew D. Seidman, Larry Norton — 2000
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• The hsp90-binding Antibiotic Geldanamycin Decreases Raf Levels and Epidermal Growth Factor Signaling without Disrupting Formation of Signaling Complexes or Reducing the Specific Enzymatic Activity of Raf Kinase*Louis F. Stancato, Adam M. Silverstein, Janet Owens‐Grillo — 1997
• Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.Lilia Stepanova, Xiaohong Leng, Susan B. Parker — 1996
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Cited by

• Heat shock protein 90 as a molecular target for cancer therapeutics.Élia Sáez Giraldez, Fernando Roch Peña — 2003
• Survival-signaling pathway as a promising target for cancer chemotherapyPatrick L. O'Connell — 2003
• The mechanisms and managements of hormone-therapy resistance in breast and prostate cancers.Richard L. Buckner, David F. Oetinger, Shareen C. Buckner — 2005
• Targeting hypoxia and angiogenesis through HIF-1alpha inhibitionJ.C. Arboniés Ortiz, E. Muñoz Seco — 2005
• A Multi-Pronged Modulation of Signaling Pathways in Targeting Breast Cancer Stem Cells.Hsiu-Fang Lee — 2012
• INTEGRATION OF HSP90 INHIBITION IN COMBINATIONAL IMMUNOTHERAPIES TARGETING RECEPTOR TYROSINE KINASE EPHA2Aparna Rao — 2012
• Novel Agents for the Prevention of Breast Cancer: Targeting Transcription Factors and Signal Transduction PathwaysQiang Shen, Powel H. Brown — 2004
• From the bench to the bed side: PI3K pathway inhibitors in clinical development.Saveur-Michel Maira, Peter M. Finan, Carlos Garcı́a-Echeverrı́a — 2010
• HSP90 inhibitors for cancer therapy and overcoming drug resistance.Komal Jhaveri, Shanu Modi — 2012
• Signal transduction mediated by cyclin D1: from mitogens to cell proliferation: a molecular target with therapeutic potential.C. Wang, Zhiping Li, Maofu Fu — 2004
• Régulation de l’activité transcriptionnelle des récepteurs des estrogènes (ER) par le récepteur à chimiokine CXCR4 et les récepteurs à activité tyrosine kinase ErbB2 et ErbB3Karine Sauvé — 2014
• Geldanamycin treatment reduces neovascularization in a mouse model of retinopathy of prematurityNorbert Kociok, Tim U. Krohne, Vassiliki Poulaki — 2005
• Black tea polyphenols induce human leukemic cell cycle arrest by inhibiting Akt signalingBabli Halder, Shubho Das Gupta, Aparna Gomes — 2012
• Estudio del valor patogénico de la expresión y ruta de señalización de KIT e IGF1R en Sarcoma de Ewing: ¿nuevas posibles dianas terapeúticas?Ana Sofia da Silva Martins — 2011
• The ErbB2 receptor and breast carcinoma cell migration : memo is a novel mediator of cell motilityRomina Marone — 2003
• Heat Shock Protein 90 Is Critical for Regulation of Phenotype and Functional Activity of Human T Lymphocytes and NK CellsJooeun Bae, Aditya Munshi, Li Cheng — 2013
• Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol.David B. Solit, Andrea Basso, Adam B. Olshen — 2003
• Heat shock protein 90 inhibition by 17-allylamino-17- demethoxygeldanamycin: a novel therapeutic approach for treating hormone-refractory prostate cancer.Len Neckers — 2002
• ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumorMercè Juliachs, Wilmar Castillo, August Vidal — 2013
• Functional Interactions Between Par-1b Protein Kinase and RNF41 E3 Ubiquitin LigaseKatherine Vega — 2012

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