Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity.
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Summary
S1P is confirmed as a potent endothelial cell chemoattractant through G(1alpha2)-coupled Edg receptors linked to Rho-associated kinase and p38 MAP kinase activation and the divergence in signaling pathways evoked by S1P and VEGF suggests complex and agonist-specific regulation of endothelialcell angiogenic responses.
- Type
- article
- Published
- 2001-06-01
- Cited by
- 149
- References
- 50
- OpenAlex
- https://openalex.org/W1856672768
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10108170
Keywords
S1PR1, Cell biology, Biology, Vascular endothelial growth factor, Cell migration
References
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- Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate
- p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells
- Activation of a High Affinity G Protein-coupled Plasma Membrane Receptor by Sphingosine-1-phosphate (*)
- Vascular Endothelial Growth Factor (VEGF)-driven Actin-based Motility Is Mediated by VEGFR2 and Requires Concerted Activation of Stress-activated Protein Kinase 2 (SAPK2/p38) and Geldanamycin-sensitive Phosphorylation of Focal Adhesion Kinase*
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- Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt.
- Sphingosine 1‐phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis
- Differential Coupling of the Sphingosine 1-Phosphate Receptors Edg-1, Edg-3, and H218/Edg-5 to the Gi, Gq, and G12 Families of Heterotrimeric G Proteins*
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Cited by
- Neuropilin-1-mediated Vascular Permeability Factor/Vascular Endothelial Growth Factor-dependent Endothelial Cell Migration*
- Sphingosine 1-phosphate receptor expression profile and regulation of migration in human thyroid cancer cells.
- Dissecting the Role of the S1P/S1PR Axis in Health and Disease
- Therapeutic potential of targeting SK1 in human cancers.
- Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity
- Investigations Into The Chemoselective Modification Of THAM Directed Towards Biological Applications
- Pharmacological relevance and potential of sphingosine 1‐phosphate in the vascular system
- Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1.
- Physiological and Pathological Angiogenesis in the Adult Pulmonary Circulation
- The Mammalian Sterile 20–like 1 Kinase Controls Selective CCR7-Dependent Functions in Human Dendritic Cells
- Positive Modulation of IL-12 Signaling by Sphingosine Kinase 2 Associating with the IL-12 Receptor β1 Cytoplasmic Region 1
- Triple negative breast cancer: a multi-omics network discovery strategy for candidate targets and driving pathways.
- Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation.
- A novel Src kinase inhibitor, M475271, inhibits VEGF-induced human umbilical vein endothelial cell proliferation and migration.
- Serum factors involved in human microvascular endothelial cell morphogenesis.
- Signal Transduction of Sphingosine-1-Phosphate G Protein—Coupled Receptors
- ATP Augments von Willebrand Factor-dependent Shear-induced Platelet Aggregation through Ca2+-Calmodulin and Myosin Light Chain Kinase Activation*
- Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3).
- Heterotrimeric G proteins, Focal Adhesion Kinase, and Endothelial Barrier Function
- Shear stress–induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases
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