Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F
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Summary
Results suggest that Ap12 encodes a protein with properties known to be characteristic of transcription factor E2F, which is expressed predominantly at the G1-S boundary and in the S phase of the cell cycle.
- Type
- article
- Published
- 1992-12-01
- Cited by
- 343
- References
- 68
- Access
- Open access
- OpenAlex
- https://openalex.org/W1873059808
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21940211
Keywords
Biology, Leucine zipper, E2F, Transactivation, Transcription factor
References
- E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor.
- The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.
- The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.
- Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.
- Molecular genetics of the retinoblastoma suppressor gene.
- A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway.
- Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma.
- Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung.
- Expression of the retinoblastoma gene product in bladder carcinoma cells associates with a low frequency of tumor formation.
- The adenovirus-inducible factor E2F stimulates transcription after specific DNA binding
- Use of T7 RNA polymerase to direct expression of cloned genes.
- Regulation of the yeast HO gene.
- Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein.
- The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity
- cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.
- GAL4-VP16 is an unusually potent transcriptional activator
- Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F
- Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex.
- The Retinoblastoma Protein Region Required for Interaction with the E2F Transcription Factor Includes the T/E1A Binding and Carboxy-Terminal Sequences
- The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.
Cited by
- Tumor induction and tissue atrophy in mice lacking E2F-1.
- PSAT1 regulates cyclin D1 degradation and sustains proliferation of non‐small cell lung cancer cells
- Integration of the PRB and P53 Cell Cycle Control Pathways
- Big brothers are watching: the retinoblastoma family and growth control.
- Toward an understanding of the functional complexity of the E2F and retinoblastoma families.
- Requirements for dE2F function in proliferating cells and in post‐mitotic differentiating cells.
- Inhibition of E2F‐mediated transcription by p202.
- Start-specific transcription in yeast.
- Regulatory interactions among E2Fs and cell cycle control proteins.
- pRB, p107 and p130 as transcriptional regulators: role in cell growth and differentiation.
- Growth regulation by the E2F and DP transcription factor families.
- Transcriptional modulation by the adenovirus E1A gene.
- Introduction to the E2F family: protein structure and gene regulation.
- DP‐1: a cell cycle‐regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein.
- The p130 pocket protein: keeping order at cell cycle exit/re-entrance transitions.
- Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye.
- Pathways Linking Deregulated Proliferation to Apoptosis: a Dissertation
- Two cytodifferentiation agent-induced pathways, differentiation and apoptosis, are distinguished by the expression of human papillomavirus 16 E7 in human bladder carcinoma cells.
- Retinoblastoma protein partners.
- Histone deacetylase interacts directly with DNA topoisomerase II
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