Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons.
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Summary
Immunohistochemistry in human and rat brain revealed widespread cytoplasmic labeling of huntingtin within neurons, rather than the more selective pattern of axon terminal labeling characteristic of many vesicle-associated proteins.
- Type
- article
- Published
- 1995-05-01
- Cited by
- 799
- References
- 25
- Access
- Open access
- OpenAlex
- https://openalex.org/W1963552002
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18071283
Keywords
Huntingtin, Cytoplasm, Vesicle, Synaptophysin, Biology
References
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Cited by
- Chorea Huntington Tiermodelle eröffnen neue Hypothesen zu Pathophysiologie und Therapie
- Huntington's Disease and Dentatorubral‐Pallidoluysian Atrophy: Proteins, Pathogenesis and Pathology
- Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
- Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor
- Subtype‐Specific Enhancement of NMDA Receptor Currents by Mutant Huntingtin
- Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease.
- Trinucleotide repeats: mechanisms and pathophysiology.
- Alteration of intracellular structure and function of glyceraldehyde-3-phosphate dehydrogenase: a common phenotype of neurodegenerative disorders?
- Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila.
- Huntington's disease: a synaptopathy?
- Hypothesis: Huntingtin may function in membrane association and vesicular trafficking.
- Gene- and cell-based approaches for neurodegenerative disease.
- Molecular biology of Huntington's disease.
- Metabolic Dysfunction in Alzheimer’s Disease and Related Neurodegenerative Disorders
- The effects of chronic simvastatin treatment on the expression of behavioral symptoms in a transgenic mouse model of Huntington’s disease
- Huntington's disease.
- NMDA Receptors and Huntington’s Disease
- Early and Progressive Accumulation of Reactive Microglia in the Huntington Disease Brain
- The ubiquitin proteasome system in Huntington's disease
- Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease.
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