Optineurin: the Autophagy Connection
Explore this paper's citation graph
Summary
The optineurin protein is a selective autophagy receptor (or adaptor), containing an ubiquitin binding domain with the ability to bind polyubiquitinated cargoes and bring them to autophagosomes via its microtubule-associated protein 1 light chain 3-interacting domain.
- Type
- review
- Published
- 2015-07-02
- Cited by
- 87
- References
- 71
- Access
- Open access
- OpenAlex
- https://openalex.org/W745428933
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25381042
Keywords
Optineurin, Autophagy, Cell biology, Ubiquitin, BAG3
References
- Studies of optineurin, a glaucoma gene: Golgi fragmentation and cell death from overexpression of wild-type and mutant optineurin in two ocular cell types.
- Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene
- Interaction of an Adenovirus E3 14.7-Kilodalton Protein with a Novel Tumor Necrosis Factor Alpha-Inducible Cellular Protein Containing Leucine Zipper Domains
- CELLULAR AND MOLECULAR BIOLOGY OF OPTINEURIN
- Failure of Ubiquitin Proteasome System: Risk for Neurodegenerative Diseases
- Metabolic Control of Autophagy
- Recognition of bacteria in the cytosol of Mammalian cells by the ubiquitin system.
- Autophagy: Renovation of Cells and Tissues
- Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates
- A Common Pathway for a Rare Disease?
- E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Block in Autophagy
- Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy
- Selective autophagy mediated by autophagic adapter proteins
- The molecular machinery of autophagy: unanswered questions
- Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression.
- Clinical features and course of patients with glaucoma with the E50K mutation in the optineurin gene.
- A forensic path to RGC-5 cell line identification: lessons learned.
- Distribution of Optineurin Sequence Variations in an Ethnically Diverse Population of Low-tension Glaucoma Patients From the United States
- Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression
- Autophagy regulates lipid metabolism
Cited by
- Cross-Sectional Survey of Relevant Literatures as to the Current Proposed Disease Mechanisms and Treatments of Amyotrophic Lateral Sclerosis (ALS)
- Endocytic membrane trafficking and neurodegenerative disease
- The role of autophagy in axonal degeneration of the optic nerve.
- Protein folding alterations in amyotrophic lateral sclerosis.
- The fine-tuning of proteolytic pathways in Alzheimer’s disease
- Working your SOCS off: the role of ASB10 and protein degradation pathways in glaucoma
- Skeletal Muscle Regeneration in the Mouse
- Methods for Mitochondria and Mitophagy Flux Analyses in Stem Cells of Resting and Regenerating Skeletal Muscle.
- Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins
- Significance of optineurin mutations in glaucoma and other diseases.
- Making sense of the cause of Crohn’s – a new look at an old disease
- An investigation of ADAM-like Decysin 1 in macrophage-mediated inflammation and Crohn's Disease
- Immune regulator ABIN1 suppresses HIV-1 transcription by negatively regulating the ubiquitination of Tat
- A critical role of Hrd1 in the regulation of optineurin degradation and aggresome formation
- Interaction between optineurin and Rab1a regulates autophagosome formation in neuroblastoma cells
- WHICH WAY DO YOU PREFER TO DEATH ? Cell Death and Beyond
- Regulation of selective autophagy: the p62/SQSTM1 paradigm.
- Evolution of tools and methods for monitoring autophagic flux in mammalian cells.
- Causative Genes in Amyotrophic Lateral Sclerosis and Protein Degradation Pathways: a Link to Neurodegeneration
- Emerging understanding of the genotype-phenotype relationship in amyotrophic lateral sclerosis.
Related papers
- Structural biology of the Atg8 and Atg12 conjugation systems
- Structural basis of Atg conjugation systems essential for autophagy
- Characterisation of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major
- Mechanism of cargo-directed Atg8 conjugation during selective autophagy
- History of the Selective Autophagy Research: How Did It Begin and Where Does It Stand Today?
- The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy