The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells during Carcinogenesis.
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Summary
This study has uncovered the existence of a miR-146b-3p/PAX8/NIS regulatory circuit that may be exploited therapeutically to modulate thyroid cell differentiation and iodide uptake for improved treatment of advanced thyroid cancer.
- Type
- article
- Published
- 2015-08-17
- Cited by
- 97
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W26282166
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5989921
Keywords
Literacy, Critical literacy, Rhetoric, Scholarship, Pedagogy
References
- Identification of Novel Pax8 Targets in FRTL-5 Thyroid Cells by Gene Silencing and Expression Microarray Analysis
- Thyroid transcription factors in development, differentiation and disease
- MicroRNA‐222 and MicroRNA‐146b are tissue and circulating biomarkers of recurrent papillary thyroid cancer
- Integrated Genomic Characterization of Papillary Thyroid Carcinoma
- MicroRNA-mediated networks underlie immune response regulation in papillary thyroid carcinoma
- The role of microRNA genes in papillary thyroid carcinoma.
- High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries
- Global and Local Architecture of the Mammalian microRNA–Transcription Factor Regulatory Network
- The interplay between transcription factors and microRNAs in genome-scale regulatory networks
- The Functional Interaction between the Paired Domain Transcription Factor Pax8 and Smad3 Is Involved in Transforming Growth Factor-β Repression of the Sodium/Iodide Symporter Gene*
- MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals.
- microRNA Dysregulation in Prostate Cancer: Network Analysis Reveals Preferential Regulation of Highly Connected Nodes
- MicroRNA regulation of human protein protein interaction network.
- Cloning and characterization of the thyroid iodide transporter
- Deregulation of microRNA expression in thyroid neoplasias
- Molecular classification of thyroid nodules using high-dimensionality genomic data.
- Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy.
- Prognostic implications of miR-146b expression and its functional role in papillary thyroid carcinoma.
- Pax8 has a critical role in epithelial cell survival and proliferation
- PI3K is involved in the IGF-I inhibition of TSH-induced sodium/iodide symporter gene expression.
Cited by
- MECHANISMS IN ENDOCRINOLOGY: MicroRNA in diagnostics and therapy of thyroid cancer.
- Linking loss of sodium-iodide symporter expression to DNA damage.
- miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma
- miRNA expression and function in thyroid carcinomas: a comparative and critical analysis and a model for other cancers
- Candidate microRNAs as biomarkers of thyroid carcinoma: a systematic review, meta‐analysis, and experimental validation
- ENDOCRINE TUMOURS: Advances in the molecular pathogenesis of thyroid cancer: lessons from the cancer genome.
- MicroRNAs in the thyroid
- MicroRNA-146b: A Novel Biomarker and Therapeutic Target for Human Papillary Thyroid Cancer
- Next-generation sequencing for endocrine cancers: Recent advances and challenges
- Mechanism of Mongolian medical warm acupuncture in treating insomnia by regulating miR-101a in rats with insomnia
- Tumor suppressor protein p53 exerts negative transcriptional regulation on human sodium iodide symporter gene expression in breast cancer
- The epigenetic landscape of differentiated thyroid cancer.
- LncRNA‐PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis
- Pathological processes and therapeutic advances in radioiodide refractory thyroid cancer.
- Comprehensive characterization of differentially expressed genes in thyroid cancer.
- Haplotype‐based association of two SNPs in miR‐323b with unexplained recurrent spontaneous abortion in a Chinese Han population
- Role of iodide metabolism in physiology and cancer.
- The rs2910164 Genetic Variant of miR-146a-3p Is Associated with Increased Overall Mortality in Patients with Follicular Variant Papillary Thyroid Carcinoma
- MicroRNA-146b promotes PI3K/AKT pathway hyperactivation and thyroid cancer progression by targeting PTEN
- Identification of unique microRNAs associated with pancreatic cancer radioresistance using deep sequencing
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