Aberrant Expression of COT Is Related to Recurrence of Papillary Thyroid Cancer
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Summary
Investigation of the expression of A-, B-, C-RAF, and COT in papillary thyroid cancer and the clinical implications of aberrant expression of these genes found increased expression of COT is correlated with recurrence of PTC.
- Type
- article
- Published
- 2015-02-01
- Cited by
- 9
- References
- 54
- OpenAlex
- https://openalex.org/W25674762
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18545164
Keywords
Computer science, Business
References
- COT phosphorylates prolyl‐isomerase Pin1 to promote tumorigenesis in breast cancer
- Activation of MEK‐1 and SEK‐1 by Tpl‐2 proto‐oncoprotein, a novel MAP kinase kinase kinase.
- Integrated Genomic Characterization of Papillary Thyroid Carcinoma
- RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models.
- Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
- Vemurafenib: the first drug approved for BRAF-mutant cancer
- Hypertrophic Agonists Stimulate the Activities of the Protein Kinases c-Raf and A-Raf in Cultured Ventricular Myocytes (*)
- Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration
- Tpl2 kinase signal transduction in inflammation and cancer.
- Resistance to BRAF inhibitors: Unraveling mechanisms and future treatment options
- Different Protein Kinase C Isoforms Determine Growth Factor Specificity in Neuronal Cells
- ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers
- Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
- The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases.
- RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
- Extent of Surgery Affects Survival for Papillary Thyroid Cancer
- RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
- Pharmacological Inhibition of TPL2/MAP3K8 Blocks Human Cytotoxic T Lymphocyte Effector Functions
- Should All Patients with Subcentimeter Thyroid Nodules Undergo Fine-Needle Aspiration Biopsy and Preoperative Neck Ultrasonography to Define the Extent of Tumor Invasion?
- The therapeutic management of differentiated thyroid cancer.
Cited by
- Multinodular Goiter Spontaneous Hemorrhage in ESRD Patients Result in Acute Respiratory Failure
- Relationship of Focally Amplified Long Noncoding on Chromosome 1 (FAL1) lncRNA with E2F Transcription Factors in Thyroid Cancer
- Molecular docking and in silico ADMET study reveals 3-(5-[4-(aminomethyl) piperidin-1-yl] methyl-1h-indol-2-yl)-1h-indazole-6-carbonitrile as a potential inhibitor of cancer Osaka thyroid kinase
- A Combination of Pharmacophore Modeling, Molecular Docking and Virtual Screening Study Reveals 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)- 4H-Chromen-4-One as a Potential Anti-Cancer Agent of COT Kinase
- TPL2 expression is correlated with distant metastasis and poor prognosis in colorectal cancer.
- Expression of transcription and growth factors and the AKT/m-TOR signaling pathway components in papillary thyroid cancer
- Computational modeling reveals MAP3K8 as mediator of resistance to vemurafenib in thyroid cancer stem cells
- Simultaneous Expression of Long Non-Coding RNA FAL1 and Extracellular Matrix Protein 1 Defines Tumour Behaviour in Young Patients with Papillary Thyroid Cancer
- Identification of Single-nucleotide Alterations in MAP3K8 Gene in a Turkish Head and Neck Squamous Cell Carcinoma Patient Group
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