SAM2 encodes the second methionine S-adenosyl transferase in Saccharomyces cerevisiae: physiology and regulation of both enzymes
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Summary
The results show that the expression of the two SAM genes is regulated differently, SAM2 being induced by the presence of excess methionine in the growth medium and SAM1 being repressed under the same conditions.
- Type
- article
- Published
- 1988-12-01
- Cited by
- 137
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W1838617752
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45209337
Keywords
Biology, Complementation, Gene, Saccharomyces cerevisiae, Mutant
References
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- New M13 vectors for cloning.
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- The regulation of isoleucine-valine biosynthesis in Saccharomyces cerevisiae. 3. Properties and regulation of the activity of acetohydroxyacid synthetase.
- Differential regulation of the duplicated isocytochrome c genes in yeast.
- Nonchromosomal antibiotic resistance in bacteria: genetic transformation of Escherichia coli by R-factor DNA.
- Nucleotide sequence of the Saccharomyces cerevisiae MET25 gene.
Cited by
- Molecular investigation of candidate genes involved in the biosynthesis of dinoflagellate paralytic shellfish toxins
- Bioactivation by S-adenosylation, S-methylation, or N-methylation.
- Enhanced S‐adenosyl‐l‐methionine production in Saccharomyces cerevisiae by spaceflight culture, overexpressing methionine adenosyltransferase and optimizing cultivation
- Methionine adenosyltransferase (s-adenosylmethionine synthetase).
- Selection of amino-acid overproducer yeast mutants
- Isolation of an Arabidopsis thaliana Mutant, mto1, That Overaccumulates Soluble Methionine (Temporal and Spatial Patterns of Soluble Methionine Accumulation)
- Cloning and characterization of the metE gene encoding S-adenosylmethionine synthetase from Bacillus subtilis
- Differential regulation of S-adenosylmethionine synthetase isozymes by gibberellic acid in dwarf pea epicotyls.
- Two S-adenosylmethionine synthetase-encoding genes differentially expressed during adventitious root development in Pinus contorta
- Elements involved in S-adenosylmethionine-mediated regulation of the Saccharomyces cerevisiae MET25 gene
- Genome rearrangement in top3 mutants of Saccharomyces cerevisiae requires a functional RAD1 excision repair gene
- Methionine-mediated lethality in yeast cells at elevated temperature
- A defect in mismatch repair in Saccharomyces cerevisiae stimulates ectopic recombination between homeologous genes by an excision repair dependent process.
- Characterization of mitochondrial C1-tetrahydrofolate synthase transcript and protein expression in adult and embryonic mammalian tissues and the role of the mitochondrial one-carbon pathway in the cytoplasmic methyl cycle
- A dominant negative effect of eth-1r, a mutant allele of the Neurospora crassa S-adenosylmethionine synthetase-encoding gene conferring resistance to the methionine toxic analogue ethionine.
- Two divergent MET10 genes, one from Saccharomyces cerevisiae and one from Saccharomyces carlsbergensis, encode the alpha subunit of sulfite reductase and specify potential binding sites for FAD and NADPH
- eth-1, the Neurospora crassa locus encoding S-adenosylmethionine synthetase: molecular cloning, sequence analysis and in vivo overexpression.
- Serine and SAM Responsive Complex SESAME Regulates Histone Modification Crosstalk by Sensing Cellular Metabolism.
- Methionine adenosyltransferase: structure and function.
- TheSAM2 gene product catalyzes the formation of S-adenosyl-ethionine from ethionine inSaccharomyces cerevisiae
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