The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

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Summary

This work mapped the critical region for senescence-induced activity and identified the transcriptional regulator responsible for this regulation, GATA4, previously known as a regulator of embryonic development, which affects senescent cells and their microenvironment and suggests the existence of an independent senescENCE regulatory network that controls the SASP.

Type
article
Published
2015-09-25
Cited by
877
References
69
Access
Open access

Keywords

Senescence, Autophagy, GATA4, Transcription factor, DNA damage

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