The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
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Summary
This work mapped the critical region for senescence-induced activity and identified the transcriptional regulator responsible for this regulation, GATA4, previously known as a regulator of embryonic development, which affects senescent cells and their microenvironment and suggests the existence of an independent senescENCE regulatory network that controls the SASP.
- Type
- article
- Published
- 2015-09-25
- Cited by
- 877
- References
- 69
- Access
- Open access
- OpenAlex
- https://openalex.org/W1800944583
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11768931
Keywords
Senescence, Autophagy, GATA4, Transcription factor, DNA damage
References
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Cited by
- The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct
- Melatonin regulates PARP1 to control the senescence‐associated secretory phenotype (SASP) in human fetal lung fibroblast cells
- Autophagy and the Cell Cycle: A Complex Landscape
- The Autophagy Lysosomal Pathway and Neurodegeneration
- Targeting the DNA Damage Response in Cancer.
- GATA get a hold on senescence
- Systemic DNA damage responses in aging and diseases
- A New Pathway for Senescence Regulation
- Exposure to Carbon Ions Triggers Proinflammatory Signals and Changes in Homeostasis and Epidermal Tissue Organization to a Similar Extent as Photons
- Cellular senescence and tumor promotion: Is aging the key?
- Xylem cells cooperate in the control of lignification and cell death during plant vascular development
- A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM–p53 signaling
- Serum Interleukin-6 Levels and Pulmonary Function in Ataxia-Telangiectasia
- Amphiregulin in Cancer: New Insights for Translational Medicine.
- Low shear stress promotes atherosclerosis through activation of EndMT
- To clear, or not to clear (senescent cells)? That is the question
- GATA4 Regulates Blood-Testis Barrier Function and Lactate Metabolism in Mouse Sertoli Cells.
- Targeting Senescent Cells: Possible Implications for Delaying Skin Aging: A Mini-Review
- A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence.
- NF-κB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer
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