Krt19(+)/Lgr5(−) cells are radioresistant cancer initiating stem cells in the colon and intestine
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Summary
It is demonstrated that the intermediate filament, keratin-19 (Krt19), marks long-lived, radiation resistant cells above the crypt base that generate Lgr5+ CBCs in the colon and intestine.
- Type
- article
- Published
- 2015-06-04
- Cited by
- 195
- References
- 31
- Access
- Open access
- OpenAlex
- https://openalex.org/W1791828066
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6612456
Keywords
LGR5, Stem cell, Crypt, Biology, Radioresistance
References
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- Distinct levels of Sox9 expression mark colon epithelial stem cells that form colonoids in culture.
- Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration.
- Intestinal crypt homeostasis revealed at single stem cell level by in vivo live-imaging
- The pan-ErbB negative regulator, Lrig1, is an intestinal stem cell marker that functions as a tumor suppressor
- Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells
- Isolation and in vitro expansion of human colonic stem cells
- Recurrent R-spondin fusions in colon cancer
Cited by
- Intestinal stem cells and inflammation.
- Mathematical models of tissue stem and transit target cell divisions and the risk of radiation- or smoking-associated cancer
- DNA Damage in Stem Cells.
- Epigenetic and Immune Regulation of Colorectal Cancer Stem Cells
- Targeted deletion of p53 in Lgr5-expressing intestinal stem cells promotes colon tumorigenesis in a preclinical model of colitis-associated cancer
- Metformin and Ara-a Effectively Suppress Brain Cancer by Targeting Cancer Stem/Progenitor Cells
- Advances and perspectives of colorectal cancer stem cell vaccine.
- Stem Cells Matter in Response to Fasting.
- Homeostatic responses of colonic LGR5+ stem cells following acute in vivo exposure to a genotoxic carcinogen.
- Defining a stem cell hierarchy in the intestine: markers, caveats and controversies
- Wnt Signaling Inhibition Deprives Small Intestinal Stem Cells of Clonogenic Capacity
- Expression of Phosphorylated AMP-Activated Protein Kinase Predicts Response to Transarterial Chemoembolization in Postoperative Cases of Hepatocellular Carcinoma
- The role of keratin intermediate filaments in the colon epithelial cells
- Modeling glioblastoma heterogeneity to decipher its biology
- Characterization of sphere-forming HCT116 clones by whole RNA sequencing
- Oesophageal adenocarcinoma and gastric cancer: should we mind the gap?
- Mouse Label-Retaining Cells Are Molecularly And Functionally Distinct From Reserve Intestinal Stem Cells
- Role of EPCR in breast cancer progression and metastasis
- Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice.
- Deletion of Polycomb Repressive Complex 2 From Mouse Intestine Causes Loss of Stem Cells.
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