DNA Damage in Stem Cells.
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Summary
The pathophysiological and therapeutic implications of the molecular pathways through which stem cells cope with DNA damage are discussed.
- Type
- article
- Published
- 2017-05-04
- Cited by
- 298
- References
- 164
- Access
- Open access
- OpenAlex
- https://openalex.org/W28475867
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5462169
Keywords
Computer science
References
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- Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis
- p53 orchestrates between normal differentiation and cancer.
- The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation.
- Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells
- PRESERVATION OF GENOMIC INTEGRITY IN MOUSE EMBRYONIC STEM CELLS
- Mouse Embryonic Stem Cells
- Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation.
- RNA binding protein RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation
- Runx1 deficiency decreases ribosome biogenesis and confers stress resistance to hematopoietic stem and progenitor cells
- Krt19(+)/Lgr5(−) cells are radioresistant cancer initiating stem cells in the colon and intestine
- Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways.
- Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer
- Hypoxia Enhances the Radioresistance of Mouse Mesenchymal Stromal Cells
- Mammary Stem Cells and Tumor-Initiating Cells Are More Resistant to Apoptosis and Exhibit Increased DNA Repair Activity in Response to DNA Damage
- SOX9 Maintains Reserve Stem Cells and Preserves Radioresistance in Mouse Small Intestine
- Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer
- Inhibition of Ataxia Telangiectasia‐ and Rad3 ‐Related Function Abrogates the In Vitro and In Vivo Tumorigenicity of Human Colon Cancer Cells Through Depletion of the CD133+ Tumor‐Initiating Cell Fraction
- Distinct regulatory mechanisms and functions of p53-activated and p53-repressed DNA damage response genes in embryonic stem cells
- Mitochondrial regulation in pluripotent stem cells.
Cited by
- Emerging biomarkers for the combination of radiotherapy and immune checkpoint blockers
- Targeting Cancer Stem Cells to Overcome Chemoresistance
- Bladder cancer stem cells: clonal origin and therapeutic perspectives
- γH2AX, 53BP1 and Rad51 protein foci changes in mesenchymal stem cells during prolonged X-ray irradiation
- Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions.
- Trial watch: Immune checkpoint blockers for cancer therapy
- Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex
- Planarians Customize Their Stem Cell Responses Following Genotoxic Stress as a Function of Exposure Time and Regenerative State
- Nonsense-mediated mRNA decay: a ‘nonsense’ pathway makes sense in stem cell biology
- Everybody In! No Bouncers at Tumor Gates.
- Periarteriolar Glioblastoma Stem Cell Niches Express Bone Marrow Hematopoietic Stem Cell Niche Proteins
- A matter of life and death: stem cell survival in tissue regeneration and tumour formation
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy
- DNA Damage and Tissue Repair: What We Can Learn From Planaria
- Tumorigenic Cell Reprogramming and Cancer Plasticity: Interplay between Signaling, Microenvironment, and Epigenetics
- Unraveling the Inconsistencies of Cardiac Differentiation Efficiency Induced by the GSK3β Inhibitor CHIR99021 in Human Pluripotent Stem Cells
- The hypoxic peri-arteriolar glioma stem cell niche, an integrated concept of five types of niches in human glioblastoma.
- Genomic Instabilities, Cellular Senescence, and Aging: In Vitro, In Vivo and Aging-Like Human Syndromes
- Cytosolic DNA Sensing in Organismal Tumor Control.
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