Engineered glycocalyx regulates stem cell proliferation in murine crypt organoids
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Summary
It is shown that blocking access to LacNAc on Paneth cells leads to hyperproliferation of the neighbouring Lgr5+ stem cells, which is accompanied by the down-regulation of genes that are known as negative regulators of proliferation.
- Type
- article
- Published
- 2018-02-08
- Cited by
- 19
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W2786254040
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3921233
Keywords
LGR5, Crypt, Stem cell, Organoid, Cell biology
References
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- Fine tuning of cell signals by glycosylation.
- Altered Mucus Glycosylation in Core 1 O-Glycan-Deficient Mice Affects Microbiota Composition and Intestinal Architecture
- The intestinal crypt, a prototype stem cell compartment.
- Chemoenzymatic synthesis of GDP-l-fucose and the Lewis X glycan derivatives
- Tracking N-Acetyllactosamine on Cell Surface Glycans in vivo
- CHoMP: A Chemoenzymatic Histology Method Using Clickable Probes
- Mice Overexpressing β-1,4-Galactosyltransferase I Are Resistant to TNF-Induced Inflammation and DSS-Induced Colitis
Cited by
- Glycans as critical regulators of gut immunity in homeostasis and disease.
- Extracellular matrix-mediated regulation of cancer stem cells and chemoresistance.
- Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification
- The synthetic small molecule FL3 combats intestinal tumorigenesis via Axin1-mediated inhibition of Wnt/beta-catenin signaling
- Plasticity of Paneth cells and their ability to regulate intestinal stem cells
- Accelerated wound closure: Systematic evaluation of cellulose acetate effects on biologically active molecules release from amniotic fluid stem cells
- Selected In Situ Hybridization Methods: Principles and Application
- Mechanism by Which MC Controls Harmful Algal Blooms Revealed by Cell Morphology of Aureococcus anophagefferens
- Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation
- A single cell survey of the microbial impacts on the mouse small intestinal epithelium
- Mass spectrometry-based methods for investigating the dynamics and organization of the surfaceome: exploring potential clinical implications
- Sugar-Coated: Can Multivalent Glycoconjugates Improve upon Nature’s Design?
- Modifying the Glycocalyx of Melanoma Cells via Metabolic Glycoengineering Using N-Acetyl-d-glucosamine Analogues
- Low fucosylation defines the glycocalyx of progenitor cells and melanocytes in the human limbal stem cell niche
- DNA Aptamer-Guided Glycomimetics for Developmental Stage- Specific Glycocalyx Engineering to Control Stem Cell Differentiation
- Reprogramming the glycocalyx: Advances in glycoengineering for immunomodulation and regenerative medicine.
- Aqueous microphase separation of double hydrophilic diblock copolymers with zwitterionic and pyranose units
- Are the mRNA vaccines inducing the Sanarelli-Shwartzman phenomenon?
- The Role of Glycans in Chronic Inflammatory Gastrointestinal and Liver Disorders and Cancer
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