New tricks for old dogs: KCNQ expression and role in smooth muscle
Explore this paper's citation graph
Summary
An overview of present understanding is provided in this nascent area of KCNQ research and future directions are offered to offer guidance as to future directions.
- Type
- review
- Published
- 2009-04-01
- Cited by
- 95
- References
- 88
- Access
- Open access
- OpenAlex
- https://openalex.org/W1780476192
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21777731
Keywords
Contractility, Vascular smooth muscle, Cell biology, Ion channel, Neuroscience
References
- Urodynamic effects of the K+ channel (KCNQ) opener retigabine in freely moving, conscious rats.
- Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone.
- Potassium channel subunits encoded by the KCNE gene family: physiology and pathophysiology of the MinK-related peptides (MiRPs).
- Signal transduction pathways and gating mechanisms of native TRP‐like cation channels in vascular myocytes
- Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications
- The C‐terminus of Kv7 channels: a multifunctional module
- Two Types of K+ Channel Subunit, Erg1 and KCNQ2/3, Contribute to the M-Like Current in a Mammalian Neuronal Cell
- Functional up‐regulation of KCNA gene family expression in murine mesenteric resistance artery smooth muscle
- A constitutively open potassium channel formed by KCNQ1 and KCNE3
- Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel
- Neural KCNQ (Kv7) channels
- Physiological roles and properties of potassium channels in arterial smooth muscle.
- Calcium sparks in smooth muscle.
- Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the cognitive enhancer XE991.
- Spontaneous transient outward currents in smooth muscle cells.
- Heteromultimeric Kv1 Channels Contribute to Myogenic Control of Arterial Diameter
- KCNQ5, a Novel Potassium Channel Broadly Expressed in Brain, Mediates M-type Currents*
- KCNQ potassium channels: drug targets for the treatment of epilepsy and pain
- Regulation of the Voltage-gated K+ Channels KCNQ2/3 and KCNQ3/5 by Ubiquitination
- Modulation of ERG channels by XE991.
Cited by
- Phosphoinositide sensitivity of ion channels, a functional perspective.
- Kv7 K+ channels in airway smooth muscle cells as target for asthma therapy
- EFFECTS ON HAEMODYNAMICS, BIOCHEMICAL AND HEMATOLOGICAL CHANGES AFTER PRETREATMENT WITH THE KCNQ OPENER RETIGABINE AND DIACYGLYCEROL LIPASE INHIBITOR ON PROPOFOL IN THE MICE
- One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders
- Pharmacological dissection of Kv7.1 channels in systemic and pulmonary arteries
- Expression and function of the K+ channel KCNQ genes in human arteries
- Potent KCNQ2/3-Specific Channel Activator Suppresses In Vivo Epileptic Activity and Prevents the Development of Tinnitus
- Participation of KCNQ (Kv7) potassium channels in myogenic control of cerebral arterial diameter
- The urinary safety profile and secondary renal effects of retigabine (ezogabine): A first‐in‐class antiepileptic drug that targets KCNQ (Kv7) potassium channels
- Vasodilator signals from perivascular adipose tissue
- Distribution of M-channel subunits KCNQ2 and KCNQ3 in rat hippocampus
- Retigabine as adjunctive therapy in adults with partial-onset seizures: integrated analysis of three pivotal controlled trials.
- Targeting of Kv7.5 (KCNQ5)/KCNE channels to surface microdomains of cell membranes
- Activation of KV7 channels stimulates vasodilatation of human placental chorionic plate arteries.
- Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles.
- Functional effects of the KCNQ modulators retigabine and XE991 in the rat urinary bladder.
- Reduced anti-contractile effect of perivascular adipose tissue on mesenteric small arteries from spontaneously hypertensive rats: role of Kv7 channels.
- From Pan-Reactive KV7 Channel Opener to Subtype Selective Opener/Inhibitor by Addition of a Methyl Group
- K+ channels as potential targets for the treatment of gastrointestinal motor disorders.
- The Effects of the KCNQ Openers Retigabine and Flupirtine on Myotonia in Mammalian Skeletal Muscle Induced by a Chloride Channel Blocker
Related papers
- Contractility detection of isolated mouse papillary muscle using myotronic Myostation‐Intact device
- Effects of tween 80 on myocardial contractility of isolated hearts in toads
- The method of evaluating how the parameters of mechanical deformation affect myocardial contractility
- Selective NOS inhibition restores myocardial contractility in endotoxemic rats; however, myocardial NO content does not correlate with myocardial dysfunction.
- Minimal oxygen consumption and optimal contractility of the heart: Theoretical approach to principle of physiological control of contractility
- Normal changes of LV contractility with ageing: an echocardiographic study
- Acute effects of iron on contractile function in isolated rabbit myocardium.
- HIP-55 negatively regulates myocardial contractility at the single-cell level.
- Abstract 2375: Regulation of Cardiac Myocyte Contractility by Phospholemman