Selective NOS inhibition restores myocardial contractility in endotoxemic rats; however, myocardial NO content does not correlate with myocardial dysfunction.
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Summary
It is concluded that SMT is beneficial to myocardial contractility in this model of endotoxemia, whereas pretreatment with L-NAME is associated with further deterioration of contractility and increased mortality.
- Type
- article
- Published
- 2000-07-01
- Cited by
- 25
- References
- 34
- OpenAlex
- https://openalex.org/W1992418884
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22765338
Keywords
Contractility, Medicine, Inotrope, Internal medicine, Nitric oxide
References
- Inhibition of nitric oxide synthase augments myocardial contractile responses to beta-adrenergic stimulation.
- Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.
- Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia.
- Sphingosine Mediates the Immediate Negative Inotropic Effects of Tumor Necrosis Factor-α in the Adult Mammalian Cardiac Myocyte*
- Nitric Oxide Novel Biology with Clinical Relevance
- A comparison between the acute effects of nitric oxide synthase inhibition and fluid resuscitation on myocardial function and metabolism in entotoxemic dogs.
- Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide.
- Selective iNOS inhibition is superior to norepinephrine in the treatment of rat endotoxic shock.
- Role of nitric oxide and peroxynitrite in the cytokine-induced sustained myocardial dysfunction in dogs in vivo.
- Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.
- Negative inotropic effects of cytokines on the heart mediated by nitric oxide.
- Time course and cellular localization of lipopolysaccharide-induced inducible nitric oxide synthase messenger RNA expression in the rat in vivo.
- EFFECT OF NITRIC OXIDE SYNTHASE INHIBITION ON MYOCARDIAL CONTRACTILITY IN ANESTHETIZED NORMAL AND ENDOTOXEMIC DOGS
- NITRIC OXIDE SYNTHASE INHIBITION DOES NOT PREVENT CARDIAC DEPRESSION IN ENDOTOXIC SHOCK
- Redox signaling: nitrosylation and related target interactions of nitric oxide.
- Reperfusion injury in the endotoxin‐treated rat heart: reevaluation of the role of nitric oxide
- A SELECTIVE INHIBITOR OF INDUCIBLE NITRIC OXIDE SYNTHASE PROLONGS SURVIVAL IN A RAT MODEL OF BACTERIAL PERITONITIS: COMPARISON WITH TWO NONSELECTIVE STRATEGIES
- NITRIC OXIDE SYNTHASE IS NOT INVOLVED IN CARDIAC CONTRACTILE DYSFUNCTION IN A RAT MODEL OF ENDOTOXEMIA WITHOUT SHOCK
- Selective inhibition of the inducible nitric oxide synthase by aminoguanidine.
- Nitric oxide does not mediate lipopolysaccharide-induced myocardial depression in guinea pigs.
Cited by
- Inhibition du monoxyde d’azote dans le choc septique
- Cardiac Response to Nitric Oxide Synthase Inhibition Using Aminoguanidine in a Rat Model of Endotoxemia
- Nitric oxide: does it play a role in the heart of the critically ill?
- Time course of nitric oxide, peroxynitrite, and antioxidants in the endotoxemic heart
- Interaction of physical training and chronic nitroglycerin treatment on blood pressure, nitric oxide, and oxidants/antioxidants in the rat heart.
- Effect of Inhibition of Inducible Nitric Oxide Synthase and Guanylyl Cyclase on Endotoxin-Induced Delay in Gastric Emptying and Intestinal Transit in Mice
- Nitric oxide modifies the sarcoplasmic reticular calcium release channel in endotoxemia by both guanosine-3′,5′ (cyclic) phosphate-dependent and independent pathways*
- Nitrotyrosine-modified SERCA2: a cellular sensor of reactive nitrogen species
- Nitric oxide in shock.
- Is There NO Treatment For Severe Sepsis?
- Renal effects of nitric oxide in endotoxemia.
- Is nitric oxide overproduction the target of choice for the management of septic shock?
- Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance.
- A 4-Amino Analogue of Tetrahydrobiopterin Attenuates Endotoxin-Induced Hemodynamic Alterations and Organ Injury in Rats
- Interaction of exercise training and chronic NOS inhibition on blood pressure, heart rate, NO and antioxidants in plasma of rats.
- Inhaled nitric oxide modifies left ventricular diastolic stress in the presence of vasoactive agents in heart failure.
- Differential Role of Cyclooxygenase 1 and 2 Isoforms in the Modulation of Colonic Neuromuscular Function in Experimental Inflammation
- Critical care medicine in AJRCCM 2000.
- Role of TXNIP/NLRP3 in sepsis-induced myocardial dysfunction
- Butorphanol alleviates lipopolysaccharide-induced inflammation and apoptosis of cardiomyocytes via activation of the κ-opioid receptor
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