Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
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Summary
It is shown that the polyglutamine-containing domain of Htt, Htt exon 1 protein (Httex1p), directly binds the acetyltransferase domains of two distinct proteins: CREB-binding protein (CBP) and p300/CBP-associated factor (P/CAF).
- Type
- article
- Published
- 2001-10-18
- Cited by
- 1,241
- References
- 28
- Access
- Open access
- OpenAlex
- https://openalex.org/W1643390591
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4419980
Keywords
Neurodegeneration, Huntingtin, Histone deacetylase, Histone deacetylase 5, Biology
References
- Identification of genes that modify ataxin-1-induced neurodegeneration
- A genetic screen to identify components of the sina signaling pathway in Drosophila eye development.
- CBP/p300 in cell growth, transformation, and development.
- The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
- Protein Aggregation and Pathogenesis of Huntingtons Disease: Mechanisms and Correlations
- Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.
- Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology.
- Information Processing in the Visual Systems of Arthropods
- Protein fate in neurodegenerative proteinopathies: polyglutamine diseases join the (mis)fold.
- Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
- Ectopic and increased expression of Fasciclin II alters motoneuron growth cone guidance.
- A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
- Interference by Huntingtin and Atrophin-1 with CBP-Mediated Transcription Leading to Cellular Toxicity
- Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells.
- p300 and CBP: Partners for life and death
- Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.
- Glutamine repeats and neurodegeneration.
- High level transactivation by a modified Bombyx ecdysone receptor in mammalian cells without exogenous retinoid X receptor.
- Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.
- A rapid and sensitive assay for histone acetyl-transferase activity.
Cited by
- Trinucleotide repeat disease. The androgen receptor in spinal and bulbar muscular atrophy.
- Histone modifications in transcriptional regulation.
- Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila.
- Mechanisms of cell death in polyglutamine expansion diseases.
- Intracellular Trafficking of Histone Deacetylase 4 Regulates Neuronal Cell Death
- Drosophila as a model for human neurodegenerative disease.
- Characterization of in vitro and in vivo huntingtin proteolysis in Huntington's disease
- A Conditional Pan-Neuronal Drosophila Model of Spinocerebellar Ataxia 7 with a Reversible Adult Phenotype Suitable for Identifying Modifier Genes
- Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.
- Drosophila Models of Alzheimer's Amyloidosis: The Challenge of Dissecting the Complex Mechanisms of Toxicity of Amyloid-β 42
- Amyotrophic lateral sclerosis: from disease mechanisms to therapies.
- Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF.
- Histone H3 phosphoacetylation is critical for heroin-induced place preference
- Changes in the expression of extracellular regulated kinase (ERK 1/2) in the R6/2 mouse model of Huntington's disease after phosphodiesterase IV inhibition.
- Nebula/DSCR1 Upregulation Delays Neurodegeneration and Protects against APP-Induced Axonal Transport Defects by Restoring Calcineurin and GSK-3β Signaling
- Specific promoter deacetylation of histone H3 is conserved across mouse models of Huntington's disease in the absence of bulk changes.
- Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation
- Epigenetic Mechanisms in Repeat Expansion Disorders
- Molecular biology of Huntington's disease.
- Mécanismes moléculaires et de signalisation induits par le stress oxydatif dans des modèles in vivo de la maladie de Parkinson chez la drosophile : intoxication au paraquat et expression de l'α-synucléine
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