A genetic screen to identify components of the sina signaling pathway in Drosophila eye development.
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Summary
It is demonstrated that ectopic expression of sina in all cells behind the morphogenetic furrow disrupts normal eye development during pupation, resulting in a severely disorganized adult eye.
- Type
- article
- Published
- 1998-01-01
- Cited by
- 109
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W1863647524
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23487496
Keywords
Biology, Eye development, Genetics, Enhancer, Gene
References
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- The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs
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- Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor
- Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13.
- Induction in the developing compound eye of Drosophila: multiple mechanisms restrict R7 induction to a single retinal precursor cell.
- The glass gene encodes a zinc-finger protein required by Drosophila photoreceptor cells
- Sevenless: A Cell-Specific Homeotic Mutation of the Drosophila Eye
- Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.
- Loss of tramtrack gene activity results in ectopic R7 cell formation, even in a sina mutant background.
- Drosophila Jun mediates Ras-dependent photoreceptor determination.
- Cell-cell interaction in the Drosophila retina: the bride of sevenless gene is required in photoreceptor cell R8 for R7 cell development.
- Identification of genes that interact with the sina gene in Drosophila eye development.
- seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye.
- Star is required in a subset of photoreceptor cells in the developing Drosophila retina and displays dosage sensitive interactions with rough.
- The Ras signaling pathway in Drosophila.
- Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway.
- The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway.
Cited by
- The Drosophila Sin3 gene encodes a widely distributed transcription factor essential for embryonic viability
- The Phenotypic Analysis Of The Knockdown Of The Sin3a Complex Components And Their Role In Recruitment And Cell Proliferation
- Further molecular and genetic analysis of upSET, the MLL5 orthologue in D. melanogaster
- Corepressor proteins in Drosophila development.
- Analyzing The Interactions Of Kdm5/lid And Sin3 In Drosophila Melanogaster
- Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression
- Pausing for thought: Disrupting the early transcription elongation checkpoint leads to developmental defects and tumourigenesis
- Analysing The Effects Of Loss Of Sin3 In Drosophila Melanogaster
- Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
- Mutations modulating the Argos-regulated signaling pathway in Drosophila eye development.
- Genetic analysis of TOR signaling in Drosophila.
- A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster.
- Genetic analysis of the Drosophila DNAprim gene. The function of the 60-kd primase subunit of DNA polymerase opposes the fat facets signaling pathway in the developing eye.
- A screen for dominant modifiers of the irreC-rst cell death phenotype in the developing Drosophila retina.
- The Proliferation of Drosophila in Cancer Research: A System for the Functional Characterization of Tumor Suppressors and Oncogenes
- Drosophila lilliputian is required for proneural gene expression in retinal development
- An Evolutionarily Conserved Innate Immunity Protein Interaction Network*
- Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila
- SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development.
- Chromosomal localization links the SIN3–RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression
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