Intimate Cell Conjugate Formation and Exchange of Membrane Lipids Precede Apoptosis Induction in Target Cells during Antibody-Dependent, Granulocyte-Mediated Cytotoxicity1
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Summary
Using electron microscopy, PMN and their target cells intimately interact with the formation of interdigitating membrane protrusions and there was a mutual exchange of fluorescent membrane lipid dyes that was strongly increased in the presence of tumor-targeting Abs.
- Type
- article
- Published
- 2007-07-01
- Cited by
- 63
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W1619850380
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45619721
Keywords
Antibody-dependent cell-mediated cytotoxicity, Cytotoxicity, Granulocyte, Cell biology, Apoptosis
References
- Chimeric IgA antibodies against HLA class II effectively trigger lymphoma cell killing.
- Polymorphonuclear Granulocytes Induce Antibody-Dependent Apoptosis in Human Breast Cancer Cells1
- Chimaeric Lym-1 monoclonal antibody-mediated cytolysis by neutrophils from G-CSF-treated patients: stimulation by GM-CSF and role of Fcγ -receptors
- Capture of Target Cell Membrane Components via Trogocytosis Is Triggered by a Selected Set of Surface Molecules on T or B Cells1
- The Fc receptor for IgA (FcalphaRI, CD89).
- Changes in gravitational force affect gene expression in developing organ systems at different developmental times
- Evaluating antibodies for their capacity to induce cell-mediated lysis of malignant B cells.
- The intriguing role of polymorphonuclear neutrophils in antitumor reactions.
- Polymorphonuclear leukocytes in antibody-dependent cellular cytotoxicity.
- Neutrophils express the high affinity receptor for IgG (Fc gamma RI, CD64) after in vivo application of recombinant human granulocyte colony-stimulating factor.
- A caspase-independent pathway of MHC class II antigen-mediated apoptosis of human B lymphocytes.
- HLA class II as potential target antigen on malignant B cells for therapy with bispecific antibodies in combination with granulocyte colony-stimulating factor.
- Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase.
- Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity.
- Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma.
- Role of oxygen intermediates in cytotoxicity: Studies in chronic granulomatous disease
- Granzymes A and B are not expressed in human neutrophils.
- Renaissance of cancer therapeutic antibodies.
- Serial killing of tumor cells by cytotoxic T cells redirected with a CD19‐/CD3‐bispecific single‐chain antibody construct
- 5,6-carboxyfluorescein diacetate succinimidyl ester-labeled apoptotic and necrotic as well as detergent-treated cells can be traced in composite cell samples.
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- C-type lectin-like molecule-1 (CLL1)-targeted TRAIL augments the tumoricidal activity of granulocytes and potentiates therapeutic antibody-dependent cell-mediated cytotoxicity
- Fc receptor-dependent mechanisms of monoclonal antibody therapy of cancer.
- A Recombinant Bispecific Single-Chain Fragment Variable Specific for HLA Class II and FcαRI (CD89) Recruits Polymorphonuclear Neutrophils for Efficient Lysis of Malignant B Lymphoid Cells
- Comparative Efficiency of HIV-1-Infected T Cell Killing by NK Cells, Monocytes and Neutrophils
- β2 Integrin-mediated Cell-Cell Contact Transfers Active Myeloperoxidase from Neutrophils to Endothelial Cells*
- Different functional outcomes of intercellular membrane transfers to monocytes and T cells
- Visualization and quantification of cytotoxicity mediated by antibodies using imaging flow cytometry.
- Combined Yeast-derived β-Glucan with Anti-tumor Monoclonal Antibody for Cancer Immunotherapy
- Serial block-face scanning electron microscopy combined with double-axis electron beam tomography provides new insight into cellular relationships.
- Neutrophils as effector cells for antibody-based immunotherapy of cancer.
- Plasmodium falciparum Adhesion on Human Brain Microvascular Endothelial Cells Involves Transmigration-Like Cup Formation and Induces Opening of Intercellular Junctions
- Both activating and inhibitory Fc gamma receptors mediate rituximab-induced trogocytosis of CD20 in mice.
- Administration of alemtuzumab and G‐CSF to adults with relapsed or refractory acute lymphoblastic leukemia: results of a phase II study
- Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes
- Role of monocytes in mediating HIV-specific antibody-dependent cellular cytotoxicity.
- Tumour Cell Lines HT-29 and FaDu Produce Proinflammatory Cytokines and Activate Neutrophils In Vitro: Possible Applications for Neutrophil-Based Antitumour Treatment
- Myeloid cells as effector cells for monoclonal antibody therapy of cancer.
- HIV-specific antibody immunity mediated through NK cells and monocytes.
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