Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins.
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Summary
Since this circuit of lipoxin formation and action appears to be of physiological relevance for the resolution of inflammation, therapeutic modalities targeted at this system are likely to have fewer unwanted side effects than other candidates and current anti-inflammatory therapies.
- Type
- review
- Published
- 2001-05-01
- Cited by
- 94
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W2122458226
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:18464641
Keywords
Inflammation, Lipid signaling, Lipoxin, Immunology, Aspirin
References
- Pathologic basis of disease
- Cutting Edge: Lipoxin (LX) A4 and Aspirin-Triggered 15-Epi-LXA4 Block Allergen-Induced Eosinophil Trafficking1
- Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages1
- Lipoxin recognition sites. Specific binding of labeled lipoxin A4 with human neutrophils.
- Lipoxin B4 regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B4 analogs with increased biologic activity
- Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors.
- Deficient lipoxin synthesis: a novel platelet dysfunction in myeloproliferative disorders with special reference to blastic crisis of chronic myelogenous leukemia.
- Lipoxin A4 Inhibits IL-1β-Induced IL-6, IL-8, and Matrix Metalloproteinase-3 Production in Human Synovial Fibroblasts and Enhances Synthesis of Tissue Inhibitors of Metalloproteinases1
- Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a ‘stop’ signaling switch for aspirin‐triggered lipoxin A4
- Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells.
- Synthesis of lipoxins and other lipoxygenase products by macrophages from the rainbow trout, Oncorhynchus mykiss.
- Polyisoprenyl phosphates in intracellular signalling
- Lipid mediator networks in cell signaling: update and impact of cytokines 1
- Cyclooxygenase-2-Derived Prostaglandin E2 and Lipoxin A4 Accelerate Resolution of Allergic Edema in Angiostrongylus costaricensis-Infected Rats: Relationship with Concurrent Eosinophilia1
- Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: studies on stereospecificity of inhibition and mode of action.
- Aspirin-triggered 15-epi-lipoxin A4 (ATL) generation by human leukocytes and murine peritonitis exudates: development of a specific 15-epi-LXA4 ELISA.
- Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: role of P-selectin.
- Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs.
- Altered biosynthesis of leukotrienes and lipoxins and host defense disorders in patients with cirrhosis and ascites.
- Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo.
Cited by
- Role of Lipoxygenases and the Lipoxin A4/Annexin 1 Receptor in Ischemia-Reperfusion-Induced Gastric Mucosal Damage in Rats
- The Role of Lipids Mediators in Inflammation and Resolution
- UNIVERSIDADE FEDERAL DE PERNAMBUCO CENTRO DE CIÊNCIAS BIOLÓGICAS PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS BIOLÓGICAS ATIVIDADE ANTINOCICEPTIVA, ANTIPIRÉTICA E ANTIINFLAMATÓRIA DO EXTRATO BRUTO E DO ÁCIDO FUMARPROTOCETRÁRICO ISOLADO DE Cladonia verticillaris (LÍQUEN)
- Long-term aspirin pretreatment in the prevention of cerulein-induced acute pancreatitis in rats.
- Involvement of the Rho-Kinase/Myosin Light Chain Kinase Pathway on Human Monocyte Chemotaxis Induced by ATL-1, an Aspirin-Triggered Lipoxin A4 Synthetic Analog1
- Protective effect of the ω-3 polyunsaturated fatty acids on the schistosomiasis liver fibrosis in mice.
- RAW264.7 대식세포에서 Heme Oxygenase-1의 유도에 의한 개망초 (Erigeron annuus L.) 꽃 Methanol 추출물의 항염증 효과
- 구절초 꽃 추출물의 Nitric Oxide 생성과 Inducible Nitric Oxide Synthase 발현 억제 효과
- Lipoxins: nature’s way to resolve inflammation
- ATLa, an Aspirin-Triggered Lipoxin A4 Synthetic Analog, Prevents the Inflammatory and Fibrotic Effects of Bleomycin-Induced Pulmonary Fibrosis1
- Comparison of antioxidant, α-glucosidase inhibition and anti-inflammatory activities of the leaf and root extracts of Smilax china L.
- Imbalance between lipoxin A4 and leukotriene B4 in chronic mastitis-affected cows.
- Physiological Impact of Abnormal Lipoxin A4 Production on Cystic Fibrosis Airway Epithelium and Therapeutic Potential
- Anti-inflammatory Effect of Extracts from Folk Plants in Ulleung Island
- Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells.
- Role of Lipoxygenases and Lipoxin A4/Annexin-1 Receptor in Gastric Protection Induced by 20% Ethanol or Sodium Salicylate in Rats
- Lipoxin A4 biology in the human synovium. Role of the ALX signaling pathways in modulation of inflammatory arthritis.
- Lipoxin A4 inhibits acute edema in mice: implications for the anti-edematogenic mechanism induced by aspirin.
- Pulmonary antifibrotic mechanisms aspirin-triggered lipoxin A(4) synthetic analog.
- Endogenous anti-inflammatory mediators from arachidonate in human neutrophils.
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