Nrf2 knockout enhances intestinal tumorigenesis in Apcmin/+ mice due to attenuation of anti‐oxidative stress pathway while potentiates inflammation
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Summary
The results suggest that Nrf2KO attenuates anti‐oxidative stress pathway, induces inflammation, and increases proliferative potential in the intestinal crypts leading to enhanced intestinal carcinogenesis and adenomas in Apcmin/+.
- Type
- article
- Published
- 2014-01-01
- Cited by
- 91
- References
- 32
- OpenAlex
- https://openalex.org/W1592051611
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21394173
Keywords
Biology, Oxidative stress, Inflammation, Carcinogenesis, Knockout mouse
References
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- The genetics of hereditary colon cancer.
Cited by
- Targeting Nrf2 in inflammation and cancer
- Induction of NRF2‐mediated gene expression by dietary phytochemical flavones apigenin and luteolin
- Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol/3,3′-Diindolylmethane: Anti-Oxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer Chemopreventive Efficacy
- The transcription factor Nrf2 is decreased after spontaneous term labour in human fetal membranes where it exerts anti-inflammatory properties.
- Inflammatory pathways in the early steps of colorectal cancer development.
- Gastric Cancer After Restrictive Bariatric Surgery
- New insights from animal models of colon cancer: inflammation control as a new facet on the tumor suppressor APC gem
- Dimethyl fumarate alters microglia phenotype and protects neurons against proinflammatory toxic microenvironments.
- Liver injury attenuation by curcumin in a rat NASH model: an Nrf2 activation-mediated effect?
- Nrf1 and Nrf2 Transcription Factors Regulate Androgen Receptor Transactivation in Prostate Cancer Cells
- Nrf2: bane or blessing in cancer?
- Bovine embryo survival under oxidative‐stress conditions is associated with activity of the NRF2‐mediated oxidative‐stress‐response pathway
- NQO1 suppresses NF-κB-p300 interaction to regulate inflammatory mediators associated with prostate tumorigenesis
- Vitamin D: a custodian of cell signalling stability in health and disease.
- Cytoprotection “gone astray”: Nrf2 and its role in cancer
- MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis.
- Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon
- The gut microbiota in mouse models of inflammatory bowel disease
- Dietary Regulation of Histone Acetylases and Deacetylases for the Prevention of Metabolic Diseases
- Oncogenic functions of the transcription factor Nrf2.
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