Targeting Breast Cancer Recurrence via Hedgehog-Mediated Sensitization of Breast Cancer Stem Cells
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Summary
The hypothesis that the hedgehog signaling pathway could be targeted to subvert quiescence in stem cell populations and force these cells back into the cell cycle, thereby sensitizing them to adjuvant cancer therapeutics is put forth.
- Type
- report
- Published
- 2011-07-01
- Cited by
- 0
- References
- 51
- OpenAlex
- https://openalex.org/W1581050127
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:55606152
Keywords
Breast cancer, Hedgehog, Cancer, Medicine, Oncology
References
- p63: A New Link Between Senescence and Aging
- The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation.
- Using notches to track mammary epithelial cell homeostasis.
- p63 is a p53 homologue required for limb and epidermal morphogenesis
- Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells
- Targeting leukemic stem cells by breaking their dormancy
- Socializing with the neighbors: stem cells and their niche.
- Cellular Quiescence in Mammary Stem Cells and Breast Tumor Stem Cells: Got Testable Hypotheses?
- Repression of mammary stem/progenitor cells by p53 is mediated by notch and separable from apoptotic activity
- On mammary stem cells
- Models, mechanisms and clinical evidence for cancer dormancy
- Defining the Epithelial Stem Cell Niche in Skin
- p53 Regulates Hematopoietic Stem Cell Quiescence
- ΔNp63α is an oncogene that induces Lsh expression and promotes stem-like proliferation
- Reciprocal Intraepithelial Interactions Between TP63 and Hedgehog Signaling Regulate Quiescence and Activation of Progenitor Elaboration by Mammary Stem Cells
- p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.
- Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling
- The Tortoise and the Hair: Slow-Cycling Cells in the Stem Cell Race
- Notch Signaling in Mammary Development and Oncogenesis
- Control of the reversibility of cellular quiescence by the transcriptional repressor HES1
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